Danish-Swedish neuroscientist
Ole Kiehn (born 1958) is a Danish-Swedish
neuroscientist .
[1] He is
Professor of Integrative Neuroscience at the Department of Neuroscience,
University of Copenhagen ,
Denmark , and
professor of
neurophysiology at
Karolinska Institute ,
Sweden .
[2]
[3]
Ole Kiehn is born 1958 in
Nakskov ,
Denmark . He earned his
medical degree in 1985 and his
Doctorate in Science (D.Sci.) in 1990, both from
University of Copenhagen , Denmark.
[1]
From 1985-89 Kiehn worked as a
research associate at the Institute of Neurophysiology,
University of Copenhagen .
[1] He spent 1989-90 working as a
Postdoc at the Section of Neurobiology and Behavior at
Cornell University , US, before returning to Denmark to become a group leader at the Institute of Neurophysiology at
University of Copenhagen (1991–95). From 1995 to 2000, he was employed as a Hallas Møller Research Fellow at Department of Physiology,
University of Copenhagen , and in 1997 he became
associate professor at the same place, a position that he held until he was recruited to
Karolinska Institute in Sweden in 2001. Since 2004, Ole Kiehn is working as
professor in
neuroscience at the Department of Neuroscience at
Karolinska Institute . From 2003 to 2011 he was deputy chair of the Department of Neuroscience,
Karolinska Institute . In 2008 Kiehn became a member of the
Nobel Assembly at the Karolinska Institute and after serving as an adjunct member from 2011–14, he was elected as a member of the
Nobel Committee for Physiology or Medicine in 2014 to 2019.
[4] From 2024 - 2026 Ole Kiehn serves as President of FENS -
Federation of European Neuroscience Societies .
Since 2017, Ole Kiehn is also employed as
professor in Integrative Neuroscience at the Department of Neuroscience,
University of Copenhagen . Since 2019, Kiehn is co-editor in chief of
Current Opinion in Neurobiology .
[5]
Kiehn has published over 120 original papers and reviews and his work has been reported in scientific journals, including
Nature (journal) ,
Science (journal) ,
Cell (journal) ,
Nature Neuroscience ,
Neuron (journal) ,
PNAS ,
Nature Reviews Neuroscience among others. Kiehn’s work has elucidated the functional organization of neuronal circuits controlling movement. In his initial work he showed that vertebrate motor neurons can express transmitter-modulated plateau potentials.
[6] His continued work has shown an involvement of plateaux in disturbed motor symptoms seen after spinal cord injury.
[7]
Using molecular mouse genetic, electrophysiology and behavioral studies he has revealed the key cellular organization of spinal locomotor networks and was able to functionally discover and link specific neuronal populations in the spinal cord to the ability to produce the alternating movements between limbs during locomotion
[8]
[9]
[10]
[11] and to set the rhythm of locomotion.
[12]
[13] Kiehn has also discovered specific populations of excitatory brainstem neurons that mediate the episodic control of locomotion: the start and stop of locomotion as well as turning.
[12]
[14]
[15] These studies unravel the communication pathway between the brain and the spinal cord needed to control the expression of locomotion.
^
a
b
c
d
e Kiehn, Ole (October 2, 2017).
"CV" . in.ku.dk .
^ University of Copenhagen, Department of Neuroscience (January 29, 2019).
"Kiehn Lab" . in.ku.dk .
^
"Kiehn Laboratory" . ki.se .
^
The Nobel Committee for Physiology or Medicine
^
Editorial board of Current Opinion in Neurobiology
^ Hounsgaard, J.; Hultborn, H.; Jespersen, B.; Kiehn, O. (November 22, 1988).
"Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan" . The Journal of Physiology . 405 : 345–367.
doi :
10.1113/jphysiol.1988.sp017336 .
PMC
1190979 .
PMID
3267153 .
^ Bellardita, C.; Caggiano, V.; Leiras, R.; Caldeira, V.; Fuchs, A.; Bouvier, J.; Löw, P.; Kiehn, O. (2017).
"Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice. - PubMed - NCBI" . eLife . 6 : e23011.
doi :
10.7554/eLife.23011 .
PMC
5332159 .
PMID
28191872 .
^ Talpalar, Adolfo E.; Endo, Toshiaki; Löw, Peter; Borgius, Lotta; Hägglund, Martin; Dougherty, Kimberly J.; Ryge, Jesper; Hnasko, Thomas S.; Kiehn, Ole (22 September 2011).
"Identification of minimal neuronal networks involved in flexor-extensor alternation in the mammalian spinal cord. - PubMed - NCBI" . Neuron . 71 (6): 1071–1084.
doi :
10.1016/j.neuron.2011.07.011 .
PMID
21943604 .
S2CID
16945911 .
^ Talpalar, Adolfo E.; Bouvier, Julien; Borgius, Lotta; Fortin, Gilles; Pierani, Alessandra; Kiehn, Ole (August 1, 2013). "Dual-mode operation of neuronal networks involved in left-right alternation". Nature . 500 (7460): 85–88.
Bibcode :
2013Natur.500...85T .
doi :
10.1038/nature12286 .
PMID
23812590 .
S2CID
4427401 .
^ Butt, Simon J. B.; Kiehn, Ole (June 19, 2003).
"Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals" . Neuron . 38 (6): 953–963.
doi :
10.1016/s0896-6273(03)00353-2 .
PMID
12818180 .
S2CID
17633931 .
^ Kullander, Klas; Butt, Simon J. B.; Lebret, James M.; Lundfald, Line; Restrepo, Carlos E.; Rydström, Anna; Klein, Rudiger; Kiehn, Ole (March 21, 2003). "Role of EphA4 and EphrinB3 in local neuronal circuits that control walking". Science . 299 (5614): 1889–1892.
Bibcode :
2003Sci...299.1889K .
doi :
10.1126/science.1079641 .
PMID
12649481 .
S2CID
9275050 .
^
a
b Bouvier, Julien; Caggiano, Vittorio; Leiras, Roberto; Caldeira, Vanessa; Bellardita, Carmelo; Balueva, Kira; Fuchs, Andrea; Kiehn, Ole (November 19, 2015).
"Descending Command Neurons in the Brainstem that Halt Locomotion" . Cell . 163 (5): 1191–1203.
doi :
10.1016/j.cell.2015.10.074 .
PMC
4899047 .
PMID
26590422 .
^ Hägglund, Martin; Borgius, Lotta; Dougherty, Kimberly J.; Kiehn, Ole (February 22, 2010). "Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion". Nature Neuroscience . 13 (2): 246–252.
doi :
10.1038/nn.2482 .
PMID
20081850 .
S2CID
5347394 .
^ Caggiano, V.; Leiras, R.; Goñi-Erro, H.; Masini, D.; Bellardita, C.; Bouvier, J.; Caldeira, V.; Fisone, G.; Kiehn, O. (January 25, 2018).
"Midbrain circuits that set locomotor speed and gait selection" . Nature . 553 (7689): 455–460.
Bibcode :
2018Natur.553..455C .
doi :
10.1038/nature25448 .
PMC
5937258 .
PMID
29342142 .
^ Cregg, J. M., Leiras, R., Montalant, A., Wanken, P., Wickersham, I. R., Kiehn, O. (1 June 2020).
"Brainstem neurons that command mammalian locomotor asymmetries" . Nature Neuroscience . 23 (6): 730–740.
doi :
10.1038/s41593-020-0633-7 .
ISSN
1546-1726 .
PMC
7610510 .
PMID
32393896 .
^
"Large grant makes it possible to continue groundbreaking research in the brain" . 15 February 2024. Faculty of Health and Medical Sciences News.
^
Brain Prize 2022
^
"Hjerneforsker hædres for kortlægning af neuronale netværk, der kontrollerer motorik" . 8 October 2021.
^ University of Copenhagen, Department of Neuroscience (December 20, 2019).
"Ole Kiehn receives DKK 32 million to research integrated neural circuits" . in.ku.dk .
^
"Pioneering Neuroscientist Awarded Novo Nordisk Foundation Laureate Research Grant" . Novo Nordisk Foundation News.
^
"ERC Advanced Grants 2015 Results" (PDF) .
^
"EMBO" . EMBO .
^
"Academy of Europe: Kiehn Ole" . www.ae-info.org .
^
The Royal Swedish Academy of Sciences homepage
^
"Videnskabernes Selskab | Royal Academy" . www.royalacademy.dk .
^
The Royal Swedish Academy of Sciences News
^
"ERC Advanced Grants 2010 - Winners" . ERC: European Research Council . January 20, 2011.
^
"IRP Schellenberg Research Prize" . www.irp.ch .
International National Academics Other