In 2002 he founded Altis Biologics (a
biotech company) together with
Nuno Pires.[5][6] Duneas was appointed CEO of Altis Biologics in 2002.[4]
The company focusses on
boneregeneration.[5] Traditionally, when repairing a severe bone break involving a void, new bone is taken from the hip and donated to the required site. This results in permanent disfigurement of the hip and complications such as hip displacement, buttock
anaesthesia and severe infections during surgery. Altis Biologics developed a method to use pig bone which had been altered to make it human compatible and also make it injectable, removing the need for surgery.[3] The method is particularly suitable for use in
spinal fusion procedures.[6]
The research for this method began in 1994 and included pre-clinical and clinical studies (in collaboration with universities) that finally culminated in a product that was patented in 2006. In 2012 the method was approved by the largest South African medical aid (
Discovery Health) and since then more than 1000 patients have been implanted with the bone graft. The tissue used in the bone grafts is manufactured in South Africa, removing the previous need to import bone graft material from the USA and Europe.[3]
From 2008 until 2010 Duneas also served as managing director of Altis Biologics. He has remained CEO since 2002.[4]
In 2014 Duneas was interviewed by Alec Hogg for The Rational Perspective (hosted on BizNews) on Sizing up African Technology Opportunities.[7] At the 2017 Healthcare Innovation Summit Africa he presented on bone regeneration technologies.[8]
Awards
In 2014 Duneas and
Nuno Pires were awarded the
Innovation Prize for Africa for the Altis Osteogenic Bone Matrix. This was the first injectable treatment for injuries requiring bone grafts using a
porcine-derived
regenerative biological
implant. Duneas and Pires received US$100 000.[1][9]
Selected publications
Limited chondro-osteogenesis by recombinant human transforming growth factor-beta 1 in calvarial defects of adult baboons (Papio ursinus). (July 1996)[10]
Recombinant transforming growth factor-beta1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation. (October 1997)[11]
Transforming growth factor-beta 1: induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7). (1998)[12]
PubMed: Tissue morphogenesis and regeneration by bone morphogenetic proteins. (January 1998)[13]
Tissue Engineering of Bne, From Concept To Market (April 2, 2008)[14]
High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-β1.(2012)[15]
Enhanced activity of demineralised bone matrix augmented with xenogeneic bone morphogenetic protein complex in rats. (2012 August)[16]
Physicochemical modification of kafirin microparticles and their ability to bind bone morphogenetic protein-2 (BMP-2), for application as a biomaterial. (August 29, 2012)[17]
^Ripamonti, U; Bosch, C; van den Heever, B; Duneas, N; Melsen, B; Ebner, R (1996). "Limited chondro-osteogenesis by recombinant human transforming growth factor-beta 1 in calvarial defects of adult baboons (Papio ursinus)". J Bone Miner Res. 11 (7): 938–45.
doi:
10.1002/jbmr.5650110710.
PMID8797114.
S2CID35150016.
^Ripamonti, U; Duneas, N; Van Den Heever, B; Bosch, C; Crooks, J (1997). "Recombinant transforming growth factor-beta1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation". J Bone Miner Res. 12 (10): 1584–95.
doi:
10.1359/jbmr.1997.12.10.1584.
PMID9333119.
S2CID22639873.
^Duneas, N; Crooks, J; Ripamonti, U (1998). "Transforming growth factor-beta 1: induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7)". Growth Factors. 15 (4): 259–77.
doi:
10.3109/08977199809017482.
PMID9714911.
^Ripamonti, U; Duneas, N (1998). "Tissue morphogenesis and regeneration by bone morphogenetic proteins". Plast Reconstr Surg. 101 (1): 227–39.
doi:
10.1097/00006534-199801000-00040.
PMID9427942.
^Sibiya, SJ; Olivier, EI; Duneas, N (2013). "High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-β1". J Biomed Mater Res A. 101 (3): 641–6.
doi:
10.1002/jbm.a.34365.
PMID22927042.
^Mohangi, GU; Rothman, B; van Zyl, AW; Duneas, N (2012). "Enhanced activity of demineralised bone matrix augmented with xenogeneic bone morphogenetic protein complex in rats". South African Dental Journal. 67 (7): 354–8.
PMID23951792.