Napsin-a

NAPSA
Identifiers
Aliases	NAPSA, KAP, Kdap, NAP1, NAPA, SNAPA, napsin A aspartic peptidase
External IDs	OMIM: 605631; MGI: 109365; HomoloGene: 68418; GeneCards: NAPSA; OMA: NAPSA - orthologs
Gene location ( Human)
Chr.	Chromosome 19 (human)
End	50,365,830 bp
Gene location ( Mouse)
Chr.	Chromosome 7 (mouse)
End	44,236,286 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; upper lobe of lung; ; upper lobe of left lung; ; visceral pleura; ; right lung; ; human kidney; ; testicle; ; right uterine tube; ; mucosa of transverse colon; ; caput epididymis;
	Top expressed in
	right kidney; ; human kidney; ; left lung; ; right lung; ; left lung lobe; ; right lung lobe; ; proximal tubule; ; spleen; ; granulocyte; ; tibiofemoral joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	endopeptidase activity; hydrolase activity; aspartic-type endopeptidase activity; peptidase activity;
Cellular component	extracellular region; lysosome; extracellular exosome; alveolar lamellar body; multivesicular body lumen; extracellular space;
Biological process	surfactant homeostasis; protein catabolic process; proteolysis; membrane protein proteolysis; autophagy;
	Sources: Amigo / QuickGO
Orthologs
	9476
	16541
	ENSG00000131400
	ENSMUSG00000002204
	O96009
	O09043
	NM_004851
	NM_008437
	NP_004842
	NP_032463
	Wikidata
View/Edit Human	View/Edit Mouse

Napsin-A is an aspartic proteinase that is encoded in humans by the NAPSA gene.^[5] The name napsin comes from novel aspartic proteinase of the pepsin family.^[6]

The activation peptide of an aspartic proteinase acts as an inhibitor of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.^[5]

Utility

Detection of NAPSA gene expression can be used to distinguish adenocarcinomas from other forms of lung cancer.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131400 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002204 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: NAPSA napsin A aspartic peptidase".
^ Tatnell PJ, Powell DJ, Hill J, Smith TS, Tew DG, Kay J (11 December 1998). "Napsins: new human aspartic proteinases". FEBS Letters. 441 (1): 43–48. doi: 10.1016/s0014-5793(98)01522-1. PMID 9877162. S2CID 27656626.
^ Ueno T, Linder S, Elmberger G (2004). "Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma". Br. J. Cancer. 88 (8): 1229–33. doi: 10.1038/sj.bjc.6600879. PMC 2747556. PMID 12698189.

Koelsch G, Mares M, Metcalf P, Fusek M (1994). "Multiple functions of pro-parts of aspartic proteinase zymogens". FEBS Lett. 343 (1): 6–10. Bibcode: 1994FEBSL.343....6K. doi: 10.1016/0014-5793(94)80596-2. PMID 8163018. S2CID 32345795.
Blundell TL, Guruprasad K, Albert A, et al. (1998). Aspartic Proteinases. Adv. Exp. Med. Biol. Vol. 436. pp. 1–13. doi: 10.1007/978-1-4615-5373-1_1. ISBN 978-1-4613-7452-7. PMID 9561193.
Chuman Y, Bergman A, Ueno T, et al. (2000). "Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas". FEBS Lett. 462 (1–2): 129–34. doi: 10.1016/S0014-5793(99)01493-3. PMID 10580105. S2CID 23355055.
Schauer-Vukasinovic V, Bur D, Kling D, et al. (2000). "Human napsin A: expression, immunochemical detection, and tissue localization". FEBS Lett. 462 (1–2): 135–9. doi: 10.1016/S0014-5793(99)01458-1. PMID 10580106. S2CID 32798620.
Yan R, Bienkowski MJ, Shuck ME, et al. (1999). "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity". Nature. 402 (6761): 533–7. Bibcode: 1999Natur.402..533Y. doi: 10.1038/990107. PMID 10591213. S2CID 4320087.
Cook M, Bühling F, Ansorge S, et al. (2002). "Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells". Biochim. Biophys. Acta. 1577 (1): 10–6. doi: 10.1016/s0167-4781(02)00400-1. PMID 12151090.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brasch F, Ochs M, Kahne T, et al. (2004). "Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung". J. Biol. Chem. 278 (49): 49006–14. doi: 10.1074/jbc.M306844200. PMID 13129928.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". Nat. Cell Biol. 6 (4): 319–27. doi: 10.1038/ncb1105. PMID 15048123. S2CID 22767022.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131400 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002204 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NAPSA napsin A aspartic peptidase".

[6] Tatnell PJ, Powell DJ, Hill J, Smith TS, Tew DG, Kay J (11 December 1998). "Napsins: new human aspartic proteinases". FEBS Letters. 441 (1): 43–48. doi: 10.1016/s0014-5793(98)01522-1. PMID 9877162. S2CID 27656626.

[7] Ueno T, Linder S, Elmberger G (2004). "Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma". Br. J. Cancer. 88 (8): 1229–33. doi: 10.1038/sj.bjc.6600879. PMC 2747556. PMID 12698189.

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Utility

References

Further reading