NLRP10, short for
NOD-like receptor family
pyrin domain containing 10, is an
intracellular protein of mammals that functions in
apoptosis and the
immune system. It is also known as NALP10, NOD8, PAN5, Pynod, and CLR11.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of
cytoplasmic receptors, although it differs from other NOD-like receptors by lacking the characteristic
leucine-rich repeat domain. It is also believed that it helps regulate the inflammatory response. NLRP10 reduces
inflammatory and
innate immune responses by
inhibiting the activity of two proteins associated with the
inflammasome;
caspase-1 and
PYCARD.[5][6]
Ha HJ, Kim DS, Hahn Y (2009). "A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence". Biochem. Genet. 47 (9–10): 665–70.
doi:
10.1007/s10528-009-9262-2.
PMID19544093.
S2CID31002187.
Ha HJ, Kim DS, Hahn Y (2009). "A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence". Biochem. Genet. 47 (9–10): 665–70.
doi:
10.1007/s10528-009-9262-2.
PMID19544093.
S2CID31002187.