From Wikipedia, the free encyclopedia
Chemical compound
N-Desethylisotonitazene
Routes of administration
Oral , intransal, vaporized
Legal status
N-ethyl-2-[5-nitro-2-[(4-propoxyphenyl)methyl]benzimidazol-1-yl]ethanamine
CAS Number
PubChem
CID
UNII
Formula C 21 H 26 N 4 O 3
Molar mass 382.464 g·mol−1 3D model (
JSmol )
CCNCCN1C2=C(C=C(C=C2)[N+](=O)[O-])N=C1CC3=CC=C(C=C3)OC(C)C
InChI=1S/C21H26N4O3/c1-4-22-11-12-24-20-10-7-17(25(26)27)14-19(20)23-21(24)13-16-5-8-18(9-6-16)28-15(2)3/h5-10,14-15,22H,4,11-13H2,1-3H3
Key:HHBRZWRJZICFRP-UHFFFAOYSA-N
N -Desethylisotonitazene (norisotonitazene) is a
benzimidazole opioid with potent
analgesic effects which has been sold as a
designer drug . It was first identified in 2023 as an active
metabolite of the closely related compound
isotonitazene , and was found to have similar potency. It is one of the strongest
benzimidazole opioids discovered, with an
analgesic strength 20 times stronger than
fentanyl .
Starting in 2023, it has become an increasingly widespread drug of abuse in its own right, linked to numerous
overdose cases, and may be considered an analog of the schedule 1 drug
metonitazene . In October 2023, the
DEA published an intent to temporarily schedule
etonitazepipne and N-desethylisotonitazene. As of April 2024, it is not yet controlled in the United States.
[1]
[2]
[3]
[4]
[5]
[6]
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See also
References
^ Krotulski AJ, Papsun DM, Kacinko SL, Logan BK (July 2020).
"Isotonitazene Quantitation and Metabolite Discovery in Authentic Forensic Casework" . Journal of Analytical Toxicology . 44 (6): 521–530.
doi :
10.1093/jat/bkaa016 .
PMID
32091095 .
^ Vandeputte MM, Van Uytfanghe K, Layle NK, St Germaine DM, Iula DM, Stove CP (April 2021).
"Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of "Nitazene" 2-Benzylbenzimidazole Synthetic Opioids" . ACS Chemical Neuroscience . 12 (7): 1241–1251.
doi :
10.1021/acschemneuro.1c00064 .
hdl :
1854/LU-8714061 .
PMID
33759494 .
S2CID
232337929 .
^ Walton SE, Krotulski AJ, Logan BK (March 2022).
"A Forward-Thinking Approach to Addressing the New Synthetic Opioid 2-Benzylbenzimidazole Nitazene Analogs by Liquid Chromatography-Tandem Quadrupole Mass Spectrometry (LC-QQQ-MS)" . Journal of Analytical Toxicology . 46 (3): 221–231.
doi :
10.1093/jat/bkab117 .
PMC
8935987 .
PMID
34792157 .
^ Vandeputte MM, Tsai MM, Chen L, Glatfelter GC, Walther D, Stove CP, et al. (May 2023). "Comparative neuropharmacology of structurally distinct non-fentanyl opioids that are appearing on recreational drug markets worldwide". Drug and Alcohol Dependence . 249 : 109939.
doi :
10.1016/j.drugalcdep.2023.109939 .
PMC 10330921.
PMID
37276825 .
S2CID
258880063 .
^ Malcolm NJ, Palkovic B, Sprague DJ, Calkins MM, Lanham JK, Halberstadt AL, Stucke AG, McCorvy JD. Mu-opioid Receptor Selective Superagonists Produce
Prolonged Respiratory Depression. ISCIENCE (2023)
doi :
10.1016/j.isci.2023.107121
^ Taylor M (30 January 2023).
"Opioid 20x More Potent than Fentanyl Detected in Pennsylvania, Florida" . Forensic .
^
"Federal Register :: Request Access" .