MyoD family inhibitor domain containing is a
protein that in humans is encoded by the MDFIC
gene.
[5]
Function
This
gene product is a member of a family of proteins characterized by a specific
cysteine-rich C-terminal domain, which is involved in
transcriptional regulation of
viral genome
expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two
isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the
cytoplasm, whereas p40 is targeted to the
nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain.
Alternative splicing results in multiple transcript variants.