Miroslav Radman (born April 30, 1944) is a
Croatian biologist.
Biography
Radman was born in
Split,
PR Croatia,
Yugoslavia. From 1962–1967 he studied experimental biology,
physical chemistry and
molecular biology at the
University of Zagreb and in 1969 he obtained a doctorate degree in
molecular biology at the
Free University of Brussels. He spent the next three years at
Harvard University as a
postdoctoral researcher. From 1973 until 1983 he was Professor of Molecular Biology at the Free University of Brussels and from 1983 until 1998 the Research Director at the French Centre for Scientific Research at the University of Paris 7. He is now a professor of
cellular biology at the Faculté de Médecine – Necker, Université Paris V,
Paris, France. In 2002 he became a full member of the French Academy of Sciences, the first
Croat to do so in the Academy's history. Radman is a co-founder of the Mediterranean Institute For Life Sciences located in
Split,
Croatia.[1][2]
Scientific work
Radman's specialty is
DNA repair. His work with
Evelyn M. Witkin set the basis for the discovery of the
SOS response. The
SOS response hypothesis was put forward by Radman in 1970 in a letter sent to various researchers, and later published in 1974.[3][4]
With his group he demonstrated the molecular mechanism of speciation by showing that
DNA mismatch repair mechanism prevents
recombination between similar
chromosomes which leads to establishment of genetic barriers between species.[5]
Richard Lounsbery Award – Joint Award of the French and U.S. national academies of science for the discovery of
DNA mismatch repair as genetic barrier between related species
Science Award (2000) from the “U.S. Environmental Mutagen Society” for "far-reaching research contributions to understanding the profound consequences of mutation and recombination, in global genomic responses, DNA repair, cancer and evolution"
^Radman, M (1974). "Phenomenology of an inducible mutagenic DNA repair pathway in Escherichia coli: SOS repair hypothesis". In L. Prakash, F. Sherman, M. Miller, C. Lawrence and H. W. Tabor (Ed.), Molecular and Environmental Aspects of Mutagenesis. Charles C Thomas, Springfield, III. 6: 128–142.
^Radman, M (1975). "Phenomenology of an inducible mutagenic DNA repair pathway in Escherichia coli: SOS repair pichulein hypothesis". Basic Life Sciences. 5A: 355–367.
doi:
10.1007/978-1-4684-2895-7_48.
PMID1103845.
^Rayssiguier C.; Thales DS.; Radman M. (1989). "The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants". Nature. 342 (6248): 396–401.
Bibcode:
1989Natur.342..396R.
doi:
10.1038/342396a0.
PMID2555716.
S2CID4308035.