Michael Belkin is an Israeli academic and researcher working in
ophthalmology, Professor Emeritus of Ophthalmology at
Tel Aviv University. His research brought about advances in glaucoma treatment such as the ExPress glaucoma implant,[1] the Ioptimate CO2 laser glaucoma surgery and a fast, non-contact glaucoma laser treatment.
He established and was the inaugural director of the Tel Aviv University Eye Research Institute, located at the Sheba Medical Center.[2][3][4]
Belkin served as head of the Research, Development and Non-Conventional Warfare Medicine department of the Israel Defence Forces Medical Corps for three years. During that time, he development military goggles to protect the eyes of soldiers.[2]
He also publicized the threat of laser radiation to the eye and endeavoured to develop treatment for laser-induced eye injuries.[6]
Belkin is a Senior Scientific Advisor to the Singapore National Eye Centre.[7] [18] Belkin founded Belkin Laser Ltd. in 2013 and served as the company's Chief Medical Officer.[8][9] He serves on the board and scientific advisory board of various companies engaged in developing novel ophthalmic technologies.[2]
Belkin has been a voting member of SPIE, the International Society for Optics and Photonics for 11 years, and serves on the organization's Conference Program Committee.[10]
Developments in ophthalmologic technology
Belkin developed the novel External Automatic Glaucoma Laser (EAGLE), a Direct Selective Trabeculoplasty (DSLT) device to change conventional glaucoma management from a specialized procedure to a procedure which general ophthalmologists can perform. Belkin's company BELKIN Laser Ltd was part of a multidisciplinary, multinational consortium that successfully received EU funding of 2480275 Euros in 2016. Under the project title GLAUrious this consortium aimed to ease commercialization of the EAGLE technology and drive adoption by general ophthalmologists.
Sheba Medical Centre carried out the first-in Human Clinical trials of the EAGLE. Their results found that their automated DSLT is a safe and effective method for reducing intraocular pressure.[11]
GLAUrious began clinical trials in Italy at the
University of Genoa and in the UK at Queens University Belfast and Moorfields Eyes Hospital, London in 2018.[12] In 1998, he developed a novel miniature glaucoma shunt, named ex-PRESS.[5] The implant is commonly used in glaucoma surgery.[1] He was involved in developing and clinically proving a method to treat adult amblyopia (lazy eye), an achievement which was previously considered impossible.[13] He also invented methods of automatic measuring visual function in children[14] and binocular treatment of amblyopia.[citation needed]
Belkin is named as inventor or co-inventor on 16 patents registered in the United States and as inventor or applicant on 30 patents globally.[15]
Research and findings
Belkin identified a correlation between the development of myopia and years of schooling and intelligence in a substantial male population aged 17–19.[16]
He was one of the first to prove that reducing visual acuity in the elderly, mostly due to improperly fitted or non-use of eyeglasses is associated with reduced cognitive functions.[17]
Belkin was part of the team investigating the implantation of pre-treated macrophages into rats stimulated tissue repair. This procedure was later extended to human trials for spinal injury patients and established that humans could tolerate the procedure.[18][19] He was one of the first to use stem cells in vascular and ophthalmic diseases clinically.[20]
Belkin was part of a team researching the link between cigarette smoking and ocular disease, both through tobacco and exposure to passive smoke.
Solberg, Yoram; Rosner, Mordechai; Belkin, Michael (1998). "The Association Between Cigarette Smoking and Ocular Diseases". Survey of Ophthalmology. 42 (6): 535–547.
doi:
10.1016/s0039-6257(98)00002-2.
PMID9635902.
Knoller, Nachshon; Auerbach, Gustavo; Fulga, Valentin; Zelig, Gabriel; Attias, Josef; Bakimer, Ronit; Marder, Jonathan B.; Yoles, Eti; Belkin, Michael; Schwartz, Michal; Hadani, Moshe (2005). "Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: Phase I study results". Journal of Neurosurgery: Spine. 3 (3): 173–181.
doi:
10.3171/spi.2005.3.3.0173.
PMID16235699.
Solberg, Y.; Belkin, M. (1997). "The role of excitotoxicity in organophosphorous nerve agents central poisoning". Trends in Pharmacological Sciences. 18 (6): 183–185.
doi:
10.1016/s0165-6147(97)89540-5.
PMID9226993.
Surinchak, John S.; Alago, Maria L.; Bellamy, Ronald F.; Stuck, Bruce E.; Belkin, Michael (1983). "Effects of low-level energy lasers on the healing of full-thickness skin defects". Lasers in Surgery and Medicine. 2 (3): 267–274.
doi:
10.1002/lsm.1900020310.
PMID6843266.
S2CID33939164.
Hirschberg, David L.; Yoles, Eti; Belkin, Michael; Schwartz, Michal (1994). "Inflammation after axonal injury has conflicting consequences for recovery of function: Rescue of spared axons is impaired but regeneration is supported". Journal of Neuroimmunology. 50 (1): 9–16.
doi:
10.1016/0165-5728(94)90209-7.
PMID8300861.
S2CID3810035.
Assia, Ehud; Rosner, Mordechai; Belkin, Michael; Solomon, Arie; Schwartz, Michal (1989). "Temporal parameters of low energy laser irradiation for optimal delay of post-traumatic degeneration of rat optic nerve". Brain Research. 476 (2): 205–212.
doi:
10.1016/0006-8993(89)91240-7.
PMID2702463.
S2CID13302840.
Solberg, Yoram; Alcalay, Menachem; Belkin, Michael (1997). "Ocular injury by mustard gas". Survey of Ophthalmology. 41 (6): 461–466.
doi:
10.1016/s0039-6257(97)00021-0.
PMID9220568.
Eitan, S; Solomon, A; Lavie, V; Yoles, E; Hirschberg, D.; Belkin, M; Schwartz, M (17 June 1994). "Recovery of visual response of injured adult rat optic nerves treated with transglutaminase". Science. 264 (5166): 1764–1768.
Bibcode:
1994Sci...264.1764E.
doi:
10.1126/science.7911602.
PMID7911602.
Schwartz, M; Belkin, M; Yoles, E; Solomon, A (1996). "Potential treatment modalities for glaucomatous neuropathy: neuroprotection and neuroregeneration". Journal of Glaucoma. 5 (6): 427–32.
doi:
10.1097/00061198-199612000-00012.
PMID8946301.
S2CID32199067.
Schwartz, M.; Solomon, A.; Lavie, V.; Ben-Bassat, S.; Belkin, M.; Cohen, A. (1991). "Tumor necrosis factor facilitates regeneration of injured central nervous system axons". Brain Research. 545 (1–2): 334–338.
doi:
10.1016/0006-8993(91)91309-o.
PMID1860055.
S2CID20900035.
Cohen, Yuval; Belkin, Michael; Yehezkel, Oren; Solomon, Arieh S.; Polat, Uri (2011). "Dependency between light intensity and refractive development under light–dark cycles". Experimental Eye Research. 92 (1): 40–46.
doi:
10.1016/j.exer.2010.10.012.
PMID21055401.