Martha Mitchell may refer to:

• Martha Mitchell (1918-1976), wife of John N. Mitchell, United States Attorney General under President Richard Nixon
• Martha Reed Mitchell (1818-1902), American philanthropist and socialite
• Martha Mitchell (author) (died 2011), American librarian and archivist
• Martha Mitchell (director), American television director.

• Martha Mitchell effect, process by which a medical professional labels a patient's accurate perception of real events as delusional

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