Oviduct-specific glycoprotein also known as oviductal glycoprotein(OGP) or estrogen-dependent oviduct protein, oviductin or mucin-9 is a
protein that in humans is encoded by the OVGP1gene.[5][6][7]
Function
Oviduct-specific glycoprotein is a large, carbohydrate-rich,
epithelialglycoprotein with numerous O-glycosylation sites located within
threonine,
serine, and
proline-rich tandem repeats. The gene is similar to members of the
mucin and the
glycosyl hydrolase 18 gene families. Regulation of expression may be
estrogen-dependent. Gene expression and protein secretion occur during late
follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated
oviductal epithelial cells and associates with ovulated
oocytes,
blastomeres, and spermatozoon
acrosomal regions.[7]
Beyond the
oviduct, OVGP1 is detected in the mouse
ovary,
testis and
epididymis suggesting its roles beyond fertilization. It is not detected in the mouse uterus, cervix, vagina, breast, seminal vesicles and prostate gland [8]
OVGP1 is expressed by the surface epithelium of the
endometrium at the time of
embryo implantation in the mouse. It is required for maintain the receptivity phenotype and trophoblast adhesion, OVGP1 mRNA levels are reduced in endometrium of women with recurrent
implantation failure.[9]
Verhage HG, Fazleabas AT, Donnelly K (1988). "The in vitro synthesis and release of proteins by the human oviduct". Endocrinology. 122 (4): 1639–45.
doi:
10.1210/endo-122-4-1639.
PMID3278893.
Iontcheva I, Oppenheim FG, Troxler RF (1997). "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins". J. Dent. Res. 76 (3): 734–43.
doi:
10.1177/00220345970760030501.
PMID9109822.
S2CID39525421.
Iontcheva I, Oppenheim FG, Offner GD, Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system". J. Dent. Res. 79 (2): 732–9.
doi:
10.1177/00220345000790020601.
PMID10728974.
S2CID27558675.