MR-2096 is an opioid
analgesic drug related to
oxymorphone. It has an unusual chiral tetrahydrofuran-2-ylmethyl substitution on the nitrogen which determines the character of effects, with the (R) enantiomer MR-2096 being an opioid agonist, while the (S) enantiomer MR-2097 has similarly potent
opioid antagonist effects. This mix of activities has made these two enantiomers useful for characterising the binding site of the
mu opioid receptor.[1]
^Ramabadran K, Jen MF (April 1985). "Opioid agonist and antagonist properties of diastereoisomeric N-tetrahydronoroxymorphones in mice". Archives Internationales de Pharmacodynamie et de Therapie. 274 (2): 180–8.
PMID4040738.