Mkln1

MKLN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PQQ
Identifiers
Aliases	MKLN1, TWA2, muskelin 1
External IDs	OMIM: 605623; MGI: 1351638; HomoloGene: 8305; GeneCards: MKLN1; OMA: MKLN1 - orthologs
Gene location ( Human)
Chr.	Chromosome 7 (human)
End	131,496,632 bp
Gene location ( Mouse)
Chr.	Chromosome 6 (mouse)
End	31,493,746 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; jejunal mucosa; ; buccal mucosa cell; ; nipple; ; lower lobe of lung; ; epithelium of colon; ; testicle; ; corpus callosum; ; secondary oocyte; ; tail of epididymis;
	Top expressed in
	spermatocyte; ; yolk sac; ; right kidney; ; muscle of thigh; ; spermatid; ; ventricular zone; ; granulocyte; ; tail of embryo; ; neural layer of retina; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	identical protein binding; protein binding; protein homodimerization activity;
Cellular component	cytoplasm; ruffle; cytosol; cell projection; cell cortex; ubiquitin ligase complex; nucleoplasm; nucleus; cell junction; synapse;
Biological process	actin cytoskeleton reorganization; cell-matrix adhesion; signal transduction; regulation of cell shape; regulation of receptor internalization;
	Sources: Amigo / QuickGO
Orthologs
	4289
	27418
	ENSG00000128585
	ENSMUSG00000025609
	Q9UL63
	O89050
	NM_001145354; NM_013255; NM_001321316
	NM_013791
	NP_001138826; NP_001308245; NP_037387
	NP_038819
	Wikidata
View/Edit Human	View/Edit Mouse

Muskelin is a protein that in humans is encoded by the MKLN1 gene.^[5]^[6]

Interactions

MKLN1 has been shown to interact with RANBP9.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128585 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025609 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adams JC, Zhang L (May 2000). "cDNA cloning of human muskelin and localisation of the muskelin (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH". Cytogenet Cell Genet. 87 (1–2): 19–21. doi: 10.1159/000015385. PMID 10640805. S2CID 7919425.
^ "Entrez Gene: MKLN1 muskelin 1, intracellular mediator containing kelch motifs".
^ Umeda, M; Nishitani H; Nishimoto T (Jan 2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene. 303. Netherlands: 47–54. doi: 10.1016/S0378-1119(02)01153-8. ISSN 0378-1119. PMID 12559565.

Adams JC, Seed B, Lawler J (1998). "Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1". EMBO J. 17 (17): 4964–74. doi: 10.1093/emboj/17.17.4964. PMC 1170825. PMID 9724633.
Hasegawa H, Katoh H, Fujita H, et al. (2000). "Receptor isoform-specific interaction of prostaglandin EP3 receptor with muskelin". Biochem. Biophys. Res. Commun. 276 (1): 350–4. doi: 10.1006/bbrc.2000.3467. PMID 11006128.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Umeda M, Nishitani H, Nishimoto T (2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene. 303: 47–54. doi: 10.1016/S0378-1119(02)01153-8. PMID 12559565.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode: 2003Sci...300..767S. doi: 10.1126/science.1083423. PMC 2882961. PMID 12690205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Prag S, Collett GD, Adams JC (2004). "Molecular analysis of muskelin identifies a conserved discoidin-like domain that contributes to protein self-association". Biochem. J. 381 (Pt 2): 547–59. doi: 10.1042/BJ20040253. PMC 1133863. PMID 15084145.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: 10.1038/msb4100134. PMC 1847948. PMID 17353931.
Kobayashi N, Yang J, Ueda A, et al. (2007). "RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex". Gene. 396 (2): 236–47. doi: 10.1016/j.gene.2007.02.032. PMID 17467196.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128585 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025609 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10640805-5] Adams JC, Zhang L (May 2000). "cDNA cloning of human muskelin and localisation of the muskelin (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH". Cytogenet Cell Genet. 87 (1–2): 19–21. doi: 10.1159/000015385. PMID 10640805. S2CID 7919425.

[entrez-6] "Entrez Gene: MKLN1 muskelin 1, intracellular mediator containing kelch motifs".

[pmid12559565-7] Umeda, M; Nishitani H; Nishimoto T (Jan 2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene. 303. Netherlands: 47–54. doi: 10.1016/S0378-1119(02)01153-8. ISSN 0378-1119. PMID 12559565.

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Interactions

References

Further reading