From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Mex-3 homolog D (C. elegans) , also known as MEX3D , is a
protein that in humans is encoded by the MEX3D
gene .
[5]
[6]
Function
MEX3D is an RNA binding protein that interacts with
AU-rich elements of
Bcl-2 . Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.
[6]
Structure
MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs (
KH domain ) and a
RING domain at the C-terminus.
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000181588 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000048696 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: mex-3 homolog D (C. elegans)" .
^
a
b
c Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004).
"Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein" . J. Biol. Chem . 279 (19): 20154–66.
doi :
10.1074/jbc.M314071200 .
PMID
14769789 .
Further reading
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Buchet-Poyau K, Courchet J, Le Hir H, et al. (2007).
"Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies" . Nucleic Acids Res . 35 (4): 1289–300.
doi :
10.1093/nar/gkm016 .
PMC
1851655 .
PMID
17267406 .