From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
MAPK8IP1
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
2G01 ,
2GMX ,
2H96 ,
3OXI ,
3PTG ,
3VUD ,
3VUG ,
3VUH ,
3VUI ,
3VUK ,
3VUL ,
3VUM ,
4E73 ,
4G1W ,
4H39 ,
4HYS ,
4HYU ,
4IZY
Identifiers
Aliases
MAPK8IP1 , IB1, JIP-1, JIP1, PRKM8IP, mitogen-activated protein kinase 8 interacting protein 1External IDs
OMIM :
604641 ;
MGI :
1309464 ;
HomoloGene :
31314 ;
GeneCards :
MAPK8IP1 ;
OMA :
MAPK8IP1 - orthologs
RNA expression pattern
Bgee
Human
Mouse (ortholog)
Top expressed in C1 segment right frontal lobe anterior pituitary right hemisphere of cerebellum tibial nerve anterior cingulate cortex prefrontal cortex ventricular zone Brodmann area 9 Brodmann area 10
Top expressed in superior frontal gyrus primary visual cortex entorhinal cortex perirhinal cortex cerebellar cortex dentate gyrus of hippocampal formation granule cell superior surface of tongue gallbladder dorsomedial hypothalamic nucleus central gray substance of midbrain
More reference expression data
BioGPS
Wikidata
C-jun-amino-terminal kinase-interacting protein 1 is an
enzyme that in humans is encoded by the MAPK8IP1
gene .
[5]
[6]
The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2.
RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
[7]
Interactions
MAPK8IP1 has been shown to
interact with
MAP3K10 ,
[8]
DUSP16 ,
[9]
Mitogen-activated protein kinase 9 ,
[8]
[10]
MAPK8 ,
[10]
[11]
LRP2 ,
[12]
[13]
LRP1 ,
[12]
MAP3K12 ,
[8]
MAP2K7 ,
[8]
MAPK8IP2
[8] and
MAP3K11 .
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000121653 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000027223 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, Davis RJ (August 1997).
"A cytoplasmic inhibitor of the JNK signal transduction pathway" . Science . 277 (5326): 693–6.
doi :
10.1126/science.277.5326.693 .
PMID
9235893 .
^ Bonny C, Nicod P, Waeber G (March 1998).
"IB1, a JIP-1-related nuclear protein present in insulin-secreting cells" . J Biol Chem . 273 (4): 1843–6.
doi :
10.1074/jbc.273.4.1843 .
PMID
9442013 .
^
"Entrez Gene: MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1" .
^
a
b
c
d
e
f Yasuda J, Whitmarsh A J, Cavanagh J, Sharma M, Davis R J (October 1999).
"The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins" . Mol. Cell. Biol . 19 (10): 7245–54.
doi :
10.1128/mcb.19.10.7245 .
ISSN
0270-7306 .
PMC
84717 .
PMID
10490659 .
^ Willoughby EA, Perkins Gordon R, Collins Mary K, Whitmarsh Alan J (March 2003).
"The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK" . J. Biol. Chem . 278 (12): 10731–6.
doi :
10.1074/jbc.M207324200 .
ISSN
0021-9258 .
PMID
12524447 .
^
a
b Whitmarsh AJ, Cavanagh J, Tournier C, Yasuda J, Davis R J (September 1998). "A mammalian scaffold complex that selectively mediates MAP kinase activation".
Science . 281 (5383): 1671–4.
Bibcode :
1998Sci...281.1671W .
doi :
10.1126/science.281.5383.1671 .
ISSN
0036-8075 .
PMID
9733513 .
^ Cai Y, Lechner Mark S, Nihalani Deepak, Prindle Marc J, Holzman Lawrence B, Dressler Gregory R (January 2002).
"Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation" . J. Biol. Chem . 277 (2): 1217–22.
doi :
10.1074/jbc.M109663200 .
ISSN
0021-9258 .
PMID
11700324 .
^
a
b Gotthardt M, Trommsdorff M, Nevitt M F, Shelton J, Richardson J A, Stockinger W, Nimpf J, Herz J (August 2000).
"Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction" . J. Biol. Chem . 275 (33): 25616–24.
doi :
10.1074/jbc.M000955200 .
ISSN
0021-9258 .
PMID
10827173 .
^ Petersen HH, Hilpert Jan, Militz Daniel, Zandler Valerie, Jacobsen Christian, Roebroek Anton J M, Willnow Thomas E (February 2003).
"Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule" . J. Cell Sci . 116 (Pt 3): 453–61.
doi :
10.1242/jcs.00243 .
ISSN
0021-9533 .
PMID
12508107 .
Further reading
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13.
doi :
10.1006/abio.1996.0138 .
PMID
8619474 .
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G (1997).
"Large-Scale Concatenation cDNA Sequencing" . Genome Res . 7 (4): 353–8.
doi :
10.1101/gr.7.4.353 .
PMC
139146 .
PMID
9110174 .
Whitmarsh AJ, Cavanagh J, Tournier C, Yasuda J, Davis RJ (1998). "A mammalian scaffold complex that selectively mediates MAP kinase activation". Science . 281 (5383): 1671–4.
Bibcode :
1998Sci...281.1671W .
doi :
10.1126/science.281.5383.1671 .
PMID
9733513 .
Mooser V, Maillard A, Bonny C, Steinmann M, Shaw P, Yarnall DP, Burns DK, Schorderet DF, Nicod P (1999). "Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun –amino-terminal kinase interacting protein-1 (JIP-1) gene". Genomics . 55 (2): 202–8.
doi :
10.1006/geno.1998.5641 .
PMID
9933567 .
Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (2000).
"The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins" . Mol. Cell. Biol . 19 (10): 7245–54.
doi :
10.1128/mcb.19.10.7245 .
PMC
84717 .
PMID
10490659 .
Meyer D, Liu A, Margolis B (2000).
"Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons" . J. Biol. Chem . 274 (49): 35113–8.
doi :
10.1074/jbc.274.49.35113 .
PMID
10574993 .
Kelkar N, Gupta S, Dickens M, Davis RJ (2000).
"Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3" . Mol. Cell. Biol . 20 (3): 1030–43.
doi :
10.1128/MCB.20.3.1030-1043.2000 .
PMC
85220 .
PMID
10629060 .
Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C (2000). "The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes". Nat. Genet . 24 (3): 291–5.
doi :
10.1038/73523 .
PMID
10700186 .
S2CID
5964917 .
Bonny C, Oberson A, Steinmann M, Schorderet DF, Nicod P, Waeber G (2000).
"IB1 reduces cytokine-induced apoptosis of insulin-secreting cells" . J. Biol. Chem . 275 (22): 16466–72.
doi :
10.1074/jbc.M908297199 .
PMID
10748095 .
Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (2000).
"Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction" . J. Biol. Chem . 275 (33): 25616–24.
doi :
10.1074/jbc.M000955200 .
PMID
10827173 .
Bonny C, Oberson A, Negri S, Sauser C, Schorderet DF (2001).
"Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death" . Diabetes . 50 (1): 77–82.
doi :
10.2337/diabetes.50.1.77 .
PMID
11147798 .
Verhey KJ, Meyer D, Deehan R, Blenis J, Schnapp BJ, Rapoport TA, Margolis B (2001).
"Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules" . J. Cell Biol . 152 (5): 959–70.
doi :
10.1083/jcb.152.5.959 .
PMC
2198804 .
PMID
11238452 .
Matsuda S, Yasukawa T, Homma Y, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S, Kita Y (2001).
"c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK" . J. Neurosci . 21 (17): 6597–607.
doi :
10.1523/JNEUROSCI.21-17-06597.2001 .
PMC
6763068 .
PMID
11517249 .
Abderrahmani A, Steinmann M, Plaisance V, Niederhauser G, Haefliger JA, Mooser V, Bonny C, Nicod P, Waeber G (2001).
"The Transcriptional Repressor REST Determines the Cell-Specific Expression of the Human MAPK8IP1 Gene Encoding IB1 (JIP-1)" . Mol. Cell. Biol . 21 (21): 7256–67.
doi :
10.1128/MCB.21.21.7256-7267.2001 .
PMC
99900 .
PMID
11585908 .
Cai Y, Lechner MS, Nihalani D, Prindle MJ, Holzman LB, Dressler GR (2002).
"Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation" . J. Biol. Chem . 277 (2): 1217–22.
doi :
10.1074/jbc.M109663200 .
PMID
11700324 .
Scheinfeld MH, Roncarati R, Vito P, Lopez PA, Abdallah M, d'Adamio L (2002).
"Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP)" . J. Biol. Chem . 277 (5): 3767–75.
doi :
10.1074/jbc.M108357200 .
PMID
11724784 .
Ikeda A, Hasegawa K, Masaki M, Moriguchi T, Nishida E, Kozutsumi Y, Oka S, Kawasaki T (2002). "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway". J. Biochem . 130 (6): 773–81.
doi :
10.1093/oxfordjournals.jbchem.a003048 .
PMID
11726277 .
Hashimoto M, Hsu LJ, Rockenstein E, Takenouchi T, Mallory M, Masliah E (2002).
"alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells" . J. Biol. Chem . 277 (13): 11465–72.
doi :
10.1074/jbc.M111428200 .
PMID
11790792 .
PDB gallery
2fpd : Sad structure determination: crystal structure of the intrinsic dimerization sh3 domain of the ib1 scaffold protein
2fpe : Conserved dimerization of the ib1 src-homology 3 domain
2fpf : Crystal structure of the ib1 sh3 dimer at low resolution