From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Mastermind-like protein 2 is a
protein that in humans is encoded by the MAML2
gene .
[3]
[4]
[5]
See also
Details on the activity of the N-terminal
domain of Mastermind-like protein 2 may be found under
MamL-1 .
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000184384 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (Oct 2002).
"Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors" . Mol Cell Biol . 22 (21): 7688–700.
doi :
10.1128/MCB.22.21.7688-7700.2002 .
PMC
135662 .
PMID
12370315 .
^ Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (Dec 2002).
"Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling" . J Biol Chem . 277 (52): 50612–20.
doi :
10.1074/jbc.M209529200 .
PMID
12386158 .
^
"Entrez Gene: MAML2 mastermind-like 2 (Drosophila)" .
Further reading
Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (2001).
"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 8 (2): 85–95.
doi :
10.1093/dnares/8.2.85 .
PMID
11347906 .
Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (2003).
"t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway" . Nat. Genet . 33 (2): 208–13.
doi :
10.1038/ng1083 .
PMID
12539049 .
S2CID
23417795 .
Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G (2004). "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors". Exp. Cell Res . 292 (1): 21–8.
doi :
10.1016/j.yexcr.2003.09.007 .
PMID
14720503 .
Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G (2005). "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion". Genes Chromosomes Cancer . 43 (2): 202–5.
doi :
10.1002/gcc.20168 .
PMID
15729701 .
S2CID
39267344 .
Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H, Griffin JD (2005).
"Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation" . EMBO J . 24 (13): 2391–402.
doi :
10.1038/sj.emboj.7600719 .
PMC
1173159 .
PMID
15961999 .
Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H (2007).
"MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma" . Clin. Cancer Res . 12 (13): 3902–7.
doi :
10.1158/1078-0432.CCR-05-2376 .
PMID
16818685 .
Winnes M, Mölne L, Suurküla M, Andrén Y, Persson F, Enlund F, Stenman G (2007).
"Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas" . Genes Chromosomes Cancer . 46 (6): 559–63.
doi :
10.1002/gcc.20440 .
PMID
17334997 .
S2CID
39594598 .
Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK (2007). "CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior". Genes Chromosomes Cancer . 46 (7): 708–15.
doi :
10.1002/gcc.20458 .
PMID
17437281 .
S2CID
24634433 .
Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T (2007).
"Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23)" . Genes Chromosomes Cancer . 46 (9): 813–9.
doi :
10.1002/gcc.20467 .
PMID
17551948 .
S2CID
42629564 .