| Lymphoepithelioma-like carcinoma | |
|---|---|
 | |
| Low magnification micrograph of a lymphoepithelioma-like carcinoma showing the characteristic squamoid nests in association with clusters of lymphocytes. H&E stain. | |
| Specialty | Oncology |
Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of malignant tumor arising from the uncontrolled mitosis of transformed cells originating in epithelial tissue (or in cells that display epithelial characteristics) that bear microscopic resemblance to lymphoepithelioma ( nasopharyngeal carcinoma).
There is considerable variation in the classification of LELC—while it is perhaps most commonly considered a subtype of squamous cell carcinoma, it can also be classified as a form of large cell carcinoma (i.e. when occurring in the lung), [1] and can be considered as a separate, unique entity. [2]
In most anatomical sites, many cases are associated with the Epstein–Barr virus. [3]
In the breast, the macroscopic, microscopic, epidemiologic, and prognostic features of LELC are very similar to medullary carcinoma; EBV status is one differentiator. [4]
See also
References
- ^ Travis, William D; Brambilla, Elisabeth; Muller-Hermelink, H Konrad; et al., eds. (2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification of Tumours. Lyon: IARC Press. ISBN 92-832-2418-3. Archived from the original (PDF) on 23 August 2009. Retrieved 27 March 2010.
- ^ Skinner, NE.; Horowitz, RI.; Majmudar, B. (Oct 2000). "Lymphoepithelioma-like carcinoma of the uterine cervix". South Med J. 93 (10): 1024–7. doi: 10.1097/00007611-200010000-00017. PMID 11147469. S2CID 30613068.
- ^ Mayer, EK.; Beckley, I.; Winkler, MH. (Mar 2007). "Lymphoepithelioma-like carcinoma of the urinary bladder—diagnostic and clinical implications". Nat Clin Pract Urol. 4 (3): 167–71. doi: 10.1038/ncpuro0725. PMID 17347662. S2CID 1506647.
- ^ Lespagnard, L.; Cochaux, P.; Larsimont, D.; Degeyter, M.; Velu, T.; Heimann, R. (Apr 1995). "Absence of Epstein–Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction". American Journal of Clinical Pathology. 103 (4): 449–52. doi: 10.1093/ajcp/103.4.449. PMID 7726142.
External links
 | This oncology article is a stub. You can help Wikipedia by expanding it. |