Lugduname (from lat. Lugdunum for Lyon) is one of the most potent sweetening agents known.[1] Lugduname has been estimated to be between 220,000 and 300,000 times as sweet as
sucrose (table sugar), with estimates varying between studies. It was developed at the
University of Lyon, France in 1996.[1] Lugduname is part of a family of potent sweeteners which contain
acetic acid functional groups attached to
guanidine.[2][3]
^Chen, J.; Pattarawarapan, M.; Zhang, A. J.; Burgess, K. (2000). "Solution- and Solid-Phase Syntheses of Substituted Guanidinocarboxylic Acids". Journal of Combinatorial Chemistry. 2 (3): 276–281.
doi:
10.1021/cc990084b.
PMID10827936. Contains a synthetic method for Lugduname, see Scheme 2
^Nofre, C.; Glaser, D.; Tinti, J.-M.; Wanner, M. (2002). "Gustatory responses of pigs to sixty compounds tasting sweet to humans". Journal of Animal Physiology and Animal Nutrition. 86 (3–4): 90–96.
doi:
10.1046/j.1439-0396.2002.00361.x.
PMID11972677.