Kunene or Cunene may refer to:

Geography

• Kunene River (also spelled Cunene), Angola and Namibia
• Kunene Region, Namibia
• Cunene Province, Angola

People

• Daniel Kunene (1923–2016), South African literary scholar, translator and writer
• Dominic Kunene, Liswati football manager
• Kenny Kunene (born 1970), South African businessman
• Manqoba Kunene (born 1982), Liswati footballer
• Madala Kunene (born 1947), South African musician
• Mazisi Kunene (1930–2006), South African poet and historian
• Ntandoyenkosi Kunene, South African beauty pagent contestant
• Victor Kunene (born 1966), South African boxer

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