From Wikipedia, the free encyclopedia
Kidamycin
Names
Other names
Rubiflavin B
Identifiers
ChEMBL
ChemSpider
InChI=1S/C39H48N2O9/c1-11-17(2)26-15-25(42)29-18(3)12-23-31(37(29)50-26)36(46)32-30(35(23)45)21(27-14-24(40(7)8)33(43)19(4)48-27)13-22(34(32)44)28-16-39(6,41(9)10)38(47)20(5)49-28/h11-13,15,19-20,24,27-28,33,38,43-44,47H,14,16H2,1-10H3/b17-11+
Key: MFTJRTUKCOVIMD-GZTJUZNOSA-N
C/C=C(\C)/C1=CC(=O)C2=C(O1)C3=C(C=C2C)C(=O)C4=C(C3=O)C(=C(C=C4C5CC(C(C(O5)C)O)N(C)C)C6CC(C(C(O6)C)O)(C)N(C)C)
Properties
C 39 H 48 N 2 O 9
Molar mass
688.818 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Kidamycin is an
anthracycline
antibiotic with
anticancer activity.
[1] It was first synthesized from a strain of
streptomyces bacteria isolated from a soil sample.
[2] In clinical trials, Kindamycin showed high effect against gram positive bacteria as well as multiple cancer models including
Ehrlich ascites carcinoma , Sarcoma 180, NF-sarcoma, and Yoshida sarcoma.
[3]
References
^ Furukawa, M.; Hayakawa, I.; Ohta, G.; Iitaka, Y. (1 January 1971).
"Structure and chemistry of kidamycin" . Tetrahedron . 31 (23): 2989–2995.
doi :
10.1016/0040-4020(75)80324-3 .
^ Kanda, N. (Sep 1971).
"A new antitumor antibiotic, kidamycin. I. Isolation, purification and properties of kidamycin" . The Journal of Antibiotics . 24 (9): 599–606.
doi :
10.7164/antibiotics.24.599 .
PMID
5132247 .
^ Kanda, Nobuo; Kono, Morihiro; Asano, Kazuo (1972).
"A New Antitumor Antibiotic, Kidamycin" . The Journal of Antibiotics . 25 (10): 553–556.
doi :
10.7164/antibiotics.25.553 .
ISSN
0021-8820 .
PMID
4648309 .