From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Kinesin-like protein KIF22 is a
protein that in humans is encoded by the KIF22
gene .
[5]
[6]
[7]
The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests an essential role in metaphase chromosome alignment and maintenance.
[7]
Interactions
KIF22 has been shown to
interact with
SIAH1 .
[8]
Clinical relevance
Mutations in this gene have been shown to cause developmental disorders such as
Spondyloepimetaphyseal dysplasia with joint laxity.
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000079616 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000030677 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T (April 1996).
"Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle" . EMBO J . 15 (3): 457–67.
doi :
10.1002/j.1460-2075.1996.tb00378.x .
PMC
449964 .
PMID
8599929 .
^ Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001).
"All kinesin superfamily protein, KIF, genes in mouse and human" . Proc Natl Acad Sci U S A . 98 (13): 7004–11.
Bibcode :
2001PNAS...98.7004M .
doi :
10.1073/pnas.111145398 .
PMC
34614 .
PMID
11416179 .
^
a
b
"Entrez Gene: KIF22 kinesin family member 22" .
^ Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (2000).
"SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis" . Oncogene . 19 (52): 5997–6006.
doi :
10.1038/sj.onc.1204002 .
PMID
11146551 .
^ Min BJ, Kim N, Chung T, Kim OH, Nishimura G, Chung CY, Song HR, Kim HW, Lee HR, Kim J, Kang TH, Seo ME, Yang SD, Kim DH, Lee SB, Kim JI, Seo JS, Choi JY, Kang D, Kim D, Park WY, Cho TJ (December 2011).
"Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type" . Am. J. Hum. Genet . 89 (6): 760–6.
doi :
10.1016/j.ajhg.2011.10.015 .
PMC
3234366 .
PMID
22152677 .
Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 .
Zhang S, Nonoyama M (1994).
"The cellular proteins that bind specifically to the Epstein-Barr virus origin of plasmid DNA replication belong to a gene family" . Proc. Natl. Acad. Sci. U.S.A . 91 (7): 2843–7.
Bibcode :
1994PNAS...91.2843Z .
doi :
10.1073/pnas.91.7.2843 .
PMC
43467 .
PMID
8146198 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 .
Song J, Murakami H, Tsutsui H, et al. (1998).
"Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ)" . J. Biol. Chem . 273 (32): 20603–14.
doi :
10.1074/jbc.273.32.20603 .
PMID
9685418 .
Song J, Murakami H, Yang ZQ, et al. (1998). "Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2". Genomics . 52 (3): 374–7.
doi :
10.1006/geno.1998.5452 .
PMID
9790757 .
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics . 60 (3): 295–308.
doi :
10.1006/geno.1999.5927 .
PMID
10493829 .
Funabiki H, Murray AW (2000).
"The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement" . Cell . 102 (4): 411–24.
doi :
10.1016/S0092-8674(00)00047-7 .
PMID
10966104 .
S2CID
3010084 .
Antonio C, Ferby I, Wilhelm H, et al. (2000).
"Xkid, a chromokinesin required for chromosome alignment on the metaphase plate" . Cell . 102 (4): 425–35.
doi :
10.1016/S0092-8674(00)00048-9 .
PMID
10966105 .
S2CID
17113314 .
Germani A, Bruzzoni-Giovanelli H, Fellous A, et al. (2001).
"SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis" . Oncogene . 19 (52): 5997–6006.
doi :
10.1038/sj.onc.1204002 .
PMID
11146551 .
Levesque AA, Compton DA (2001).
"The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles" . J. Cell Biol . 154 (6): 1135–46.
doi :
10.1083/jcb.200106093 .
PMC
2150818 .
PMID
11564754 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Yajima J, Edamatsu M, Watai-Nishii J, et al. (2003).
"The human chromokinesin Kid is a plus end-directed microtubule-based motor" . EMBO J . 22 (5): 1067–74.
doi :
10.1093/emboj/cdg102 .
PMC
150335 .
PMID
12606572 .
Shiroguchi K, Ohsugi M, Edamatsu M, et al. (2003).
"The second microtubule-binding site of monomeric kid enhances the microtubule affinity" . J. Biol. Chem . 278 (25): 22460–5.
doi :
10.1074/jbc.M212274200 .
PMID
12692123 .
Ohsugi M, Tokai-Nishizumi N, Shiroguchi K, et al. (2003).
"Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes" . EMBO J . 22 (9): 2091–103.
doi :
10.1093/emboj/cdg208 .
PMC
156080 .
PMID
12727876 .
Venkatesh LK, Gettemeier T, Chinnadurai G (2003).
"A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein" . J. Virol . 77 (13): 7236–43.
doi :
10.1128/JVI.77.13.7236-7243.2003 .
PMC
164832 .
PMID
12805422 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Tokai-Nishizumi N, Ohsugi M, Suzuki E, Yamamoto T (2006).
"The chromokinesin Kid is required for maintenance of proper metaphase spindle size" . Mol. Biol. Cell . 16 (11): 5455–63.
doi :
10.1091/mbc.E05-03-0244 .
PMC
1266440 .
PMID
16176979 .