Jonathan Lewis may refer to:
- Jonathan Guy Lewis (born 1963), English actor
- Johnny Lewis (1983–2012), American actor
- Jonathan Lewis (artist) (born 1970), visual artist
- Jonathan Lewis (American football) (born 1984), American football player
- Jonathan Lewis (soccer) (born 1997), American soccer player
- Jonathan Lewis (motorsport), driver and manager
- Jon Lewis (cricketer, born 1970), English player and coach
- Jonathan Lewis (oncologist) (born 1959), oncologist and cancer drug developer
- Jonathan Lewis, American murder victim
- Jonathan Lewis (died c. 1820), alleged murderer of Omie Wise
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disambiguation page lists articles about people with the same name.
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