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French stroke researcher
Jean-Claude Baron (2022)
Jean-Claude Baron is an
Emeritus Professor of Stroke Medicine at the
University of Cambridge .
[1] He is also a Fellow of the
Academy of Medical Sciences . He has authored around 450 peer-reviewed articles.
[2]
Education
Jean-Claude Baron studied
clinical neurology at the
Pitié-Salpêtrière Hospital in Paris, medical physics at the
Commissariat à l'énergie atomique et aux énergies alternatives in
Orsay , and functional brain imaging at
Harvard University in the United States. He received his medical education and training at the
University of Paris , where he also specialized in Neurology.
[3]
Research and career
Jean-Claude Baron's principal research interests are in the pathophysiology of stroke and the processes of functional recovery after stroke, which he has mostly studied using imaging techniques.
He primarily used
positron emission tomography (PET) in the study of
cerebrovascular diseases , using it in conjunction with other techniques such as CT, MR, and SPECT to investigate the pathophysiology of
transient ischemic attacks (TIAs) and acute ischemic stroke, as well as the mechanisms underlying post-stroke recovery, in both patients and animal models.
[4]
[5]
His main findings include the discovery of the
ischemic penumbra in humans and the crucial role of
hemodynamic impairment in carotid-territory TIAs, as well as crossed cerebellar diaschisis and thalamo-cortical diaschisis.
[6]
[7]
He has used functional and structural brain imaging to examine the mechanisms underlying cerebral amyloid angiopathy and neurodegenerative illnesses such as
Alzheimer's ,
Parkinson's , and
Progressive Supranuclear Palsy .
[8]
[9]
[10]
[11]
Jean-Claude Baron has over 40 years of professional experience and is currently director of research at
INSERM and
Paris University .
[12]
[13]
Awards and honors
Jean-Claude Baron has earned various accolades including the following.
Elected Member of the Academia Europeae (2023)
[1]
Lifetime Achievement Award of the International Society for Cerebral Blood Flow and Metabolism (2023)
[2]
Fellow of the
Academy of Medical Sciences
[1]
Mémain-Pelletier Award for Biomedical Sciences from the French Academy of Sciences (2014)
[14]
Johannes Wepfer Award (2005)
[3]
Ferdinand Dreyfous Award from the French Academy of Medicine (1979)
[4]
Selected publications
Baron, J. C.; Chételat, G.; Desgranges, B.; Perchey, G.; Landeau, B.; de la Sayette, V.; Eustache, F. (2001-08-01).
"In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease" . NeuroImage . 14 (2): 298–309.
doi :
10.1006/nimg.2001.0848 .
ISSN
1053-8119 .
PMID
11467904 .
S2CID
21101432 .
Baron, J C; Bousser, M G; Rey, A; Guillard, A; Comar, D; Castaigne, P (1981-07-01).
"Reversal of focal "misery-perfusion syndrome" by extra-intracranial arterial bypass in hemodynamic cerebral ischemia. A case study with 15O positron emission tomography" . Stroke . 12 (4): 454–459.
doi :
10.1161/01.STR.12.4.454 .
PMID
6976022 .
S2CID
9904657 .
Baron, J. C.; Bousser, M. G.; Comar, D.; Castaigne, P. (1981).
" "Crossed cerebellar diaschisis" in human supratentorial brain infarction" . Transactions of the American Neurological Association . 105 : 459–461.
ISSN
0065-9479 .
PMID
19645126 .
Baron, J. C.; Bousser, M. G.; Comar, D.; Soussaline, F.; Castaigne, P. (1981).
"Noninvasive tomographic study of cerebral blood flow and oxygen metabolism in vivo. Potentials, limitations, and clinical applications in cerebral ischemic disorders" . European Neurology . 20 (3): 273–284.
doi :
10.1159/000115247 .
ISSN
0014-3022 .
PMID
6973468 .
Baron, J. C.; D'Antona, R.; Pantano, P.; Serdaru, M.; Samson, Y.; Bousser, M. G. (December 1986).
"Effects of thalamic stroke on energy metabolism of the cerebral cortex. A positron tomography study in man" . Brain: A Journal of Neurology . 109 ( Pt 6): 1243–1259.
doi :
10.1093/brain/109.6.1243 .
ISSN
0006-8950 .
PMID
3491655 .
Baron, Jean-Claude (1999).
"Mapping the Ischaemic Penumbra with PET: Implications for Acute Stroke Treatment" . Cerebrovascular Diseases . 9 (4): 193–201.
doi :
10.1159/000015955 .
ISSN
1015-9770 .
PMID
10393405 .
S2CID
44698118 .
References
^
a
b
"Professor Jean-Claude Baron | The Academy of Medical Sciences" . acmedsci.ac.uk . Retrieved 2022-06-20 .
^ Hennerici, M.; Bogousslavsky, J. (2005).
"Johann Jacob Wepfer Award 2005 of the ESC to Dr. Jean-Claude Baron" . Cerebrovascular Diseases . 20 (3): 152–153.
doi :
10.1159/000087198 .
ISSN
1015-9770 .
PMID
16088109 .
S2CID
30991427 .
^
"Loop | Jean-Claude Baron" . loop.frontiersin.org . Retrieved 2022-06-20 .
^ Ejaz, Sohail; Emmrich, Julius V.; Sawiak, Stephen J.; Williamson, David J.; Baron, Jean-Claude (2015-04-01).
"Cortical Selective Neuronal Loss, Impaired Behavior, and Normal Magnetic Resonance Imaging in a New Rat Model of True Transient Ischemic Attacks" . Stroke . 46 (4): 1084–1092.
doi :
10.1161/STROKEAHA.114.007581 .
PMID
25669312 .
S2CID
657327 .
^ Horton, Myles; Modi, Jayesh; Patel, Shiel K.; Demchuk, Andrew M.; Goyal, Mayank; Hill, Michael D.; Coutts, Shelagh B. (2013-06-21).
"Refinement of Imaging Predictors of Recurrent Events following Transient Ischemic Attack and Minor Stroke" . PLOS ONE . 8 (6): e65752.
Bibcode :
2013PLoSO...865752H .
doi :
10.1371/journal.pone.0065752 .
ISSN
1932-6203 .
PMC
3689749 .
PMID
23805187 .
^ Kang, Koung Mi; Sohn, Chul-Ho; Choi, Seung Hong; Jung, Keun-Hwa; Yoo, Roh-Eul; Yun, Tae Jin; Kim, Ji-hoon; Park, Sun-Won (2017-03-21).
"Detection of crossed cerebellar diaschisis in hyperacute ischemic stroke using arterial spin-labeled MR imaging" . PLOS ONE . 12 (3): e0173971.
Bibcode :
2017PLoSO..1273971K .
doi :
10.1371/journal.pone.0173971 .
ISSN
1932-6203 .
PMC
5360263 .
PMID
28323841 .
^ Joya, Ana; Padro, Daniel; Gómez-Vallejo, Vanessa; Plaza-García, Sandra; Llop, Jordi; Martín, Abraham (2018-12-02).
"PET Imaging of Crossed Cerebellar Diaschisis after Long-Term Cerebral Ischemia in Rats" . Contrast Media & Molecular Imaging . 2018 : e2483078.
doi :
10.1155/2018/2483078 .
ISSN
1555-4309 .
PMC
6305055 .
PMID
30627057 .
^ Ermine, Charlotte M; Bivard, Andrew; Parsons, Mark W; Baron, Jean-Claude (July 2021).
"The ischemic penumbra: From concept to reality" . International Journal of Stroke . 16 (5): 497–509.
doi :
10.1177/1747493020975229 .
ISSN
1747-4930 .
PMID
33818215 .
S2CID
229409921 .
^
"The Ischemic Penumbra" . Routledge & CRC Press . Retrieved 2022-06-20 .
^ Demeestere, Jelle; Wouters, Anke; Christensen, Soren; Lemmens, Robin; Lansberg, Maarten G. (2020-03-01).
"Review of Perfusion Imaging in Acute Ischemic Stroke" . Stroke . 51 (3): 1017–1024.
doi :
10.1161/STROKEAHA.119.028337 .
PMID
32008460 .
S2CID
211013470 .
^ Takasawa, Masashi; Jones, P. Simon; Guadagno, Joseph V.; Christensen, Soren; Fryer, Tim D.; Harding, Sally; Gillard, Jonathan H.; Williams, Guy B.; Aigbirhio, Franklin I.; Warburton, Elizabeth A.; Østergaard, Leif (2008-03-01).
"How Reliable Is Perfusion MR in Acute Stroke?" . Stroke . 39 (3): 870–877.
doi :
10.1161/STROKEAHA.107.500090 .
PMID
18258831 .
S2CID
2967625 .
^
"Professor Jean-Claude Baron :: Cambridge Neuroscience" . www.neuroscience.cam.ac.uk . Retrieved 2022-06-20 .
^
"Jean-Claude Baron / Membres de l'ATP / ATPVieillissement / Recherche - ATPVieillissement" . recherche.parisdescartes.fr . Retrieved 2022-06-20 .
^
"Calames" . www.calames.abes.fr . Retrieved 2022-06-20 .
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