James B. Clark may refer to:
- Champ Clark (James Beauchamp Clark, 1850–1921), American politician
- James B. Clark (filmmaker) (1908–2000), American film editor and director
- James B. Clark (Canadian politician) (1867–1943), Canadian politician from Ontario
- James B. Clark, Jr. (1957–1996), murderer executed in the U.S. state of Delaware
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