From Wikipedia, the free encyclopedia
Isojacareubin
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Names
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IUPAC name
6,10,11-Trihydroxy-3,3-dimethylpyrano[2,3-c]xanthen-7-one
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Identifiers
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ChemSpider
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InChI=1S/C18H14O6/c1-18(2)6-5-8-12(24-18)7-11(20)13-14(21)9-3-4-10(19)15(22)17(9)23-16(8)13/h3-7,19-20,22H,1-2H3 Key: FSTNFJKGRSHPBO-UHFFFAOYSA-N
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CC1(C=CC2=C(O1)C=C(C3=C2OC4=C(C3=O)C=CC(=C4O)O)O)C
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Properties
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C18H14O6
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Molar mass
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326.304 g·mol−1
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Isojacareubin is a
xanthonoid natural product found in
Hypericum japonicum.
[1]
It has been shown to have
antibacterial activity. Isojacareubin also inhibits
protein kinase C isoforms, and has activity in an
animal model of
hepatocellular carcinoma.
[2]
References
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^ Zuo, GY; An, J; Han, J; Zhang, YL; Wang, GC; Hao, XY; Bian, ZQ (2012).
"Isojacareubin from the Chinese Herb Hypericum japonicum: Potent Antibacterial and Synergistic Effects on Clinical Methicillin-Resistant Staphylococcus aureus (MRSA)". International Journal of Molecular Sciences. 13 (7): 8210–8.
doi:
10.3390/ijms13078210.
PMC
3430230.
PMID
22942699.
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^ Xing Yuan, Hao Chen, Xia Li, Ming Dai, Huawu Zeng, Lei Shan, Qingyan Sun & Weidong Zhang (2015).
"Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo". Scientific Reports. 5: 12889.
Bibcode:
2015NatSR...512889Y.
doi:
10.1038/srep12889.
PMC
4526861.
PMID
26245668.
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link)
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Aglycones |
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Apetalinone A,
B,
C and
D
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Bellidifolin
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Calozeyloxanthone
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Desoxygambogenin
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Desoxymorellin
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Euxanthone
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Forbesione
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Gambogellic acid
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Gambogenic acid
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Gambogenin
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Gambogenin dimethyl acetal
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Gambogic acid
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Gambogin
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Gaudichaudiic acid A,
B,
C,
D and
E
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Gaudichaudione A,
B,
C,
D,
E,
F,
G and
H
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Hanburin
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Isogambogenin
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Isojacareubin
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Isomorellin
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Isomoreollin B
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Methylswertianin
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Morellic acid
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Morellin dimethyl acetal
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Moreollic acid
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Norathyriol
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Psorospermin
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2,3′,4,6-tetrahydroxybenzophenone
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Tomentonone
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Zeyloxanthonone
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Glycosides | |
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Acetylated | |
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Misc. | |
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