From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Interferon regulatory factor 2 binding protein 2 is a
protein that in humans is encoded by the IRF2BP2
gene .
[5]
Function
This gene encodes an
interferon regulatory factor-2 (IRF2) binding protein that interacts with the
C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
References
Further reading
Childs KS, Goodbourn S (2003).
"Identification of novel co-repressor molecules for Interferon Regulatory Factor-2" . Nucleic Acids Res . 31 (12): 3016–26.
doi :
10.1093/nar/gkg431 .
PMC
162335 .
PMID
12799427 .
Tinnikov AA, Yeung KT, Das S, Samuels HH (2009).
"Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells" . Cancer Res . 69 (4): 1375–82.
doi :
10.1158/0008-5472.CAN-08-2896 .
PMC
4264605 .
PMID
19190336 .
Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010).
"IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression" . FASEB J . 24 (12): 4825–34.
doi :
10.1096/fj.10-167049 .
PMID
20702774 .
S2CID
35708173 .
Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010).
"IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression" . FASEB J . 24 (12): 4825–34.
doi :
10.1096/fj.10-167049 .
PMID
20702774 .
S2CID
35708173 .
Carneiro FR, Ramalho-Oliveira R, Mognol GP, Viola JP (2011).
"Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity" . Mol. Cell. Biol . 31 (14): 2889–901.
doi :
10.1128/MCB.00974-10 .
PMC
3133407 .
PMID
21576369 .
Teng AC, Al-Montashiri NA, Cheng BL, Lou P, Ozmizrak P, Chen HH, Stewart AF (2011).
"Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2" . PLOS ONE . 6 (8): e24100.
Bibcode :
2011PLoSO...624100T .
doi :
10.1371/journal.pone.0024100 .
PMC
3162591 .
PMID
21887377 .
Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012).
"Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma" . PLOS ONE . 7 (11): e49705.
Bibcode :
2012PLoSO...749705N .
doi :
10.1371/journal.pone.0049705 .
PMC
3504151 .
PMID
23185413 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .