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German physician and neuroscientist
Hilmar Bading in 2014
Hilmar Bading (born 1958) is a German physician and neuroscientist. He is a member of the German National Academy of Science Leopoldina.
[1]
Education and career
Hilmar Bading studied medicine from 1978 to 1984 at
Heidelberg University (MD in 1984) and carried out his MD Thesis at the
Max Planck Institute for Medical Research , Heidelberg on calcium transport ATPase in skeletal muscle. He received postdoctoral training at the
Max Planck Institute for Molecular Genetics , Berlin, Germany (1985–1989) and at
Harvard Medical School , Boston, US (1989–1993). From 1993 to 2001 he was a staff scientist at the
MRC Laboratory of Molecular Biology , Cambridge, UK. Since 2001 he has been professor of neurobiology and director of the Neurobiology Institute and the Interdisciplinary Center for Neurosciences (IZN) at Heidelberg University.
[2]
[3]
He is co-founder of FundaMental Pharma GmbH, Heidelberg.
[4]
He founded the Foundation BrainAid.
[5]
Research
Hilmar Bading's work is focused on neuronal
calcium signaling and
gene regulation in the
nervous system .
[6] He identified calcium as the principal second messenger in the coupling of neuronal activity to gene expression and characterized the processes that mediate the dialogue between the synapse and the nucleus.
[7]
[8] His work highlighted the spatial aspects of
calcium signals
[9]
[10] and in particular the importance of
nuclear calcium in governing activity-dependent gene expression and adaptations in the nervous system that include
memory formation and
acquired neuroprotection .
[11]
[12]
[13]
[14] The discovery of toxic signaling by
extrasynaptic NMDA receptors which antagonizes gene regulation by synaptic activity and causes neuronal dysfunction and
cell death
[15]
[16] contributed to the understanding of
neurodegenerative disorders including
Huntington's disease ,
Alzheimer's disease , and
amyotrophic lateral sclerosis (ALS).
[15]
[16]
[17]
[18]
[19]
[20]
Hilmar Bading and his co-workers uncovered the importance of a death signaling complex consisting of extrasynaptic NMDA receptors (NMDARs) and TRPM4 for excitotoxicity and identified a class of neuroprotective small molecules (known as NMDAR/TRPM4 interaction interface inhibitors or short ‚interface inhibitors‘) that disrupt the NMDAR/TRPM4 complex and protect against cell death in mouse models of stroke and retinal ganglion cell degeneration.
[21]
Awards and honors
2001: Wolfgang-Paul Prize of the
Alexander von Humboldt Foundation
[22]
2016: Innovation Prize of the German BioRegions
[23]
2019: Elected to the German National Academy of Science Leopoldina
[1]
References
^
a
b
"List of Members" . Nationale Akademie der Wissenschaften Leopoldina . Retrieved 2020-10-29 .
^
"Neurobiology" . Heidelberg University . Retrieved 2016-10-18 .
^
"Interdisciplinary Center for Neurosciences (IZN)" . Heidelberg University . Retrieved 2016-10-18 .
^
"www.fundamentalpharma.de" . Fundamental Pharma . 2021-06-17.
^
"Foundation Brainaid" . www.foundationbrainaid.de . Retrieved 2020-10-29 .
^ Forschung, biotechnologie.de - Initiative des Bundesministeriums für Bildung und Forschung.
"Biotechnologie.de - Menschen" . www.biotechnologie.de (in German). Retrieved 2016-09-07 .
^ Bading, H.; Ginty, D. D.; Greenberg, M. E. (1993-04-09). "Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways". Science . 260 (5105): 181–186.
Bibcode :
1993Sci...260..181B .
doi :
10.1126/science.8097060 .
ISSN
0036-8075 .
PMID
8097060 .
^ Hagenston, Anna M.; Bading, Hilmar (2011-11-01).
"Calcium signaling in synapse-to-nucleus communication" . Cold Spring Harbor Perspectives in Biology . 3 (11): a004564.
doi :
10.1101/cshperspect.a004564 .
ISSN
1943-0264 .
PMC
3220353 .
PMID
21791697 .
^ Ginty, D. D. (1997-02-01).
"Calcium regulation of gene expression: isn't that spatial?" . Neuron . 18 (2): 183–186.
doi :
10.1016/s0896-6273(00)80258-5 .
ISSN
0896-6273 .
PMID
9052789 .
S2CID
15833933 .
^ Hardingham, G. E.; Chawla, S.; Johnson, C. M.; Bading, H. (1997-01-16). "Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression". Nature . 385 (6613): 260–265.
Bibcode :
1997Natur.385..260H .
doi :
10.1038/385260a0 .
ISSN
0028-0836 .
PMID
9000075 .
S2CID
4328815 .
^ Bading, Hilmar (2013-09-01). "Nuclear calcium signalling in the regulation of brain function". Nature Reviews. Neuroscience . 14 (9): 593–608.
doi :
10.1038/nrn3531 .
ISSN
1471-0048 .
PMID
23942469 .
S2CID
14896252 .
^
"Heidelberg Researchers Identify Neuron Survival Programmes - University of Heidelberg" . www.uni-heidelberg.de . Retrieved 2016-09-07 .
^
"Mediaserver – Universität Heidelberg: Audio" . archiv.ub.uni-heidelberg.de . Retrieved 2016-09-07 .
^
Campus TV: Dem Langzeitgedächtnis auf der Spur , retrieved 2016-09-07
^
a
b Milnerwood, Austen J.; Gladding, Clare M.; Pouladi, Mahmoud A.; Kaufman, Alexandra M.; Hines, Rochelle M.; Boyd, Jamie D.; Ko, Rebecca W.Y.; Vasuta, Oana C.; Graham, Rona K. (2010-01-28).
"Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice" . Neuron . 65 (2): 178–190.
doi :
10.1016/j.neuron.2010.01.008 .
ISSN
1097-4199 .
PMID
20152125 .
S2CID
12987037 .
^
a
b Talantova, Maria; Sanz-Blasco, Sara; Zhang, Xiaofei; Xia, Peng; Akhtar, Mohd Waseem; Okamoto, Shu-ichi; Dziewczapolski, Gustavo; Nakamura, Tomohiro; Cao, Gang (2013-07-02).
"Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss" . Proceedings of the National Academy of Sciences of the United States of America . 110 (27): E2518–2527.
Bibcode :
2013PNAS..110E2518T .
doi :
10.1073/pnas.1306832110 .
ISSN
1091-6490 .
PMC
3704025 .
PMID
23776240 .
^
"Proteins Produced by Activated Neurons Could Protect Against Neurodegeneration" . 2015-08-24. Retrieved 2016-09-07 .
^ Okamoto, Shu-ichi; Pouladi, Mahmoud A.; Talantova, Maria; Yao, Dongdong; Xia, Peng; Ehrnhoefer, Dagmar E.; Zaidi, Rameez; Clemente, Arjay; Kaul, Marcus (2009-12-01).
"Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin" . Nature Medicine . 15 (12): 1407–1413.
doi :
10.1038/nm.2056 .
ISSN
1546-170X .
PMC
2789858 .
PMID
19915593 .
^ Hardingham, Giles E.; Bading, Hilmar (2010-10-01).
"Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders" . Nature Reviews. Neuroscience . 11 (10): 682–696.
doi :
10.1038/nrn2911 .
ISSN
1471-0048 .
PMC
2948541 .
PMID
20842175 .
^ Parsons, Matthew P.; Raymond, Lynn A. (2014).
"Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders" . Neuron . 82 (2): 279–293.
doi :
10.1016/j.neuron.2014.03.030 .
PMID
24742457 .
^ Yan, Jing; Bengtson, C. Peter; Buchthal, Bettina; Hagenston, Anna M.; Bading, Hilmar (9 October 2020).
"Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants" . Science . 370 (6513): eaay3302.
doi :
10.1126/science.aay3302 .
ISSN
1095-9203 .
PMID
33033186 .
S2CID
222210921 .
^
"The Wolfgang Paul Award" . Alexander von Humboldt Foundation . Retrieved 2016-10-18 .
^
"Nasenspray gegen Nervenleiden, Organmodelle statt Tierversuche, Viren gegen Krebs: Innovationspreis der BioRegionen" [Nasal spray against nervous disorders, organ models instead of animal testing, virus against cancer: Innovation Award BioRegions]. Bio Deutschland (Press release) (in German). Retrieved 2016-10-18 .
International National Academics