SC 395 begins at an
intersection with
SC 194 (Denny Highway) at a point northeast of
Saluda and west of Lake Murray, within northeastern
Saluda County. From this intersection, the roadway continues southeast as Sports Road. SC 395 travels to the north and curves to the northeast before crossing the
Saluda River, where it enters
Newberry County. It travels in a northerly direction and curves to the north-northeast. The highway crosses over the
Bush River. Then, it crosses Scott Creek, passes Gallman Elementary School, and curves to the northwest before it enters the
city limits of Newberry. The highway intersects
SC 34 (Dixie Drive). In town, it crosses
railroad tracks, passes Margaret Hunter Park, and crosses the same railroad tracks again. On the northwestern edge of Newberry, it meets its northern terminus, an intersection with
SC 121 (Kendall Road). This intersection is just southwest of Marion Davis Park.[3]