SC 389 begins at an
intersection with
SC 39 (West Railroad Avenue/Festival Trail Road) in Perry, within
Aiken County. It travels to the southeast, enters
Orangeburg County, and intersects
SC 394 (Salley Road) at a point northeast of
Salley. Less than one mile (1.6 km) later, it intersects
SC 3 (Capital Way). The highway continues to the southeast and enters the
city limits of Neeses. It curves to the east-northeast and crosses over
railroad tracks before meeting its eastern terminus, an intersection with
U.S. Route 321 (US 321; Savannah Highway). Here, the roadway continues as Ninety Six Road.[3]