SC 184 begins at the
Georgia state line, where the roadway crosses over the
Savannah River and enters that state on the Sgt. Fred M. Newton Bridge as
Georgia State Route 368 (Anderson Highway). It begins to travel through
Anderson in an east-northeast direction and then curves to the north-northwest before an
intersection with
SC 187. It curves to the northeast and crosses over Little Generostee Creek before entering
Iva. The highway turns right onto Hamilton Street. It has a
concurrency with
SC 81. At East Green Street, it meets the southern terminus of
SC 413. The two highways travel concurrently to the southeast for one block, where SC 413 splits off onto East Front Street. SC 184 then travels to the northeast, leaves Iva, and crosses East Beards Creek. It starts heading east, and crosses over
Lake Secession, into
Abbeville County, on an unnamed bridge. It then travels through part of
Lake Secession and curves to the southeast before entering Antreville. There, it begins a concurrency with
SC 28/
SC 284. Right after leaving the
city limits, SC 284 leaves the concurrency. Approximately 2,000 feet (610 m) later, SC 184 splits off to the northeast and crosses over Spur Creek. It winds its way through
rural areas of the county and crosses over Johnson Creek. A short distance later is an intersection with
SC 201 and a crossing of the
Little River. SC 184 crosses over Hogskin Creek and Chickasaw Creek before entering Due West. In town, it begins a concurrency with
SC 20/
SC 185 (Anderson Drive). The three highways pass by
Erskine Theological Seminary and
Erskine College. At College Street, SC 20/SC 185 splits off, while SC 184 continues to the northeast. In Donalds, it has a very brief concurrency with
U.S. Route 178 (US 178). Farther to the northeast, it crosses over Turkey Creek before it meets its eastern terminus, an intersection with
SC 252.[3][4]