SC 183 begins at an
intersection with
U.S. Route 76 (US 76) and
US 123 in
Westminster. It travels north to
Walhalla and then east to meet
SC 130 for a short
concurrency on Rochester Highway near the
Oconee Nuclear Station at
Lake Keowee in
Seneca in
Oconee County.[4][5] The road, known as East Pickens Highway, moves east by northeast over a
tributary that feeds into
Lake Hartwell where the road name changes to Walhalla Highway as the highway enters
Pickens County, 1.22 mi (1.96 km) eastward.[6] Upon entering Pickens County, the highway travels 4.3 mi (6.9 km) north by northeast before intersecting at
SC 133.[6] SC 183 moves 2.1 mi (3.4 km) where it intersects Six Mile Road, the northern terminus of
SC 137.[6] Traveling east by northeast on Walhalla Highway, SC 183 goes 5.8 mi (9.3 km) before reaching downtown
Pickens, the
county seat. SC 183 travels concurrently with
US 178 through downtown Pickens on Main street for 0.02 mi (0.032 km) on East Main Street.[6] The highway travels 0.19 mi (0.31 km) where it intersects
SC 8.[6] Traveling concurrently with SC 8 for 0.44 mi (0.71 km) northeastward on Jewel Road, SC 183 splits off from SC 8 to become Farrs Bridge Road.[6] SC 183 moves 5.64 mi (9.08 km) where it intersects
SC 135 at Dacusville Road.[6] It then moves eastward 8.32 mi (13.39 km) where it intersects
US 25 in
Greenville County, crossing over the
Saluda River in the process.[6][7] Traveling southeastward for 0.91 mi (1.46 km), SC 183 enters
Berea.[7] Once SC 183 passes West Parker Road, the road names changes to Cedar Lane Road, then travels an additional 1.70 mi (2.74 km) to reach West Blue Ridge Drive at
SC 253.[7] SC 183 travels an additional 1.79 mi (2.88 km) southeast, becoming Pete Hollis Boulevard, and intersecting Stone Avenue and Rutherford Street.[7] It has a second intersection with US 123 at North Academy Street in downtown Greenville a further 0.41 mi (0.66 km) southeast.[8][7][9] Then, it continues to the southeast and reaches its eastern terminus, an intersection with
US 29 (Church Street).