From Wikipedia, the free encyclopedia
Chemical compound
Hexadecanal
Names
IUPAC name
hexadecanal
Other names
Hexadecanal; AI3-24252; EINECS 211-111-0; UNII-WQD27655QE
Identifiers
1772756
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard
100.010.102
EC Number
722456
KEGG
UNII
InChI=1S/C16H32O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h16H,2-15H2,1H3
Key: NIOYUNMRJMEDGI-UHFFFAOYSA-N
Properties
C 16 H 32 O
Molar mass
240.428 g/mol
Hazards
GHS labelling :
Warning
H315 ,
H319 ,
H335
P261 ,
P264 ,
P271 ,
P280 ,
P302+P352 ,
P304+P340 ,
P305+P351+P338 ,
P312 ,
P321 ,
P332+P313 ,
P337+P313 ,
P362 ,
P403+P233 ,
P405 ,
P501
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Hexadecanal is an
organic compound with the
chemical formula C16 H32 O.
Hexadecanal is found in human skin, saliva, and feces. It has a calming effect on mice.
[1]
A 2017 study found that
neurotypical men demonstrate an increase in
electrodermal activity when exposed to
subliminal levels of hexadecanal while men with
autism spectrum disorder do not.
[2]
[3]
In 2021, inhalation of hexadecanal was found to reduce
aggression in men but to trigger aggression in women.
[4] Hexadecanal is one of the most abundant substances emitted by human babies from their heads, which may be an
evolutionary survival mechanism to induce mothers to defend the baby and fathers to not attack it. But it is not yet known whether the amount of hexadecanal emitted by humans is sufficient to affect other humans.
[5]
^ Klein, Bettina; Bautze, Verena; Maier, Anna-Maria; Deussing, Jan; Breer, Heinz; Strotmann, Jörg (2015).
"Activation of the mouse odorant receptor 37 subsystem coincides with a reduction of novel environment-induced activity within the paraventricular nucleus of the hypothalamus" .
European Journal of Neuroscience . 41 (6): 793–801.
doi :
10.1111/ejn.12838 .
PMID
25619114 .
S2CID
39197364 .
^ Endevelt-Shapira, Yaara; Perl, Ofer; Ravia, Aharon; Amir, Daniel; Eisen, Ami; Bezalel, Vered; Rozenkrantz, Liron; Mishor, Eva; Pinchover, Liron; Soroka, Timna; Honigstein, Danielle; Sobel, Noam (January 2018).
"Altered responses to social chemosignals in autism spectrum disorder" .
Nature Neuroscience . 21 (1): 111–119.
doi :
10.1038/s41593-017-0024-x .
ISSN
1546-1726 .
PMID
29180748 .
S2CID
3270677 . Retrieved 27 January 2022 .
^ Whalley, Katherine (January 2018).
"Misreading social smells" .
Nature Reviews Neuroscience . 19 (1): 3.
doi :
10.1038/nrn.2017.157 .
PMID
29213136 .
S2CID
600918 .
^ Mishor, Eva; Amir, Daniel; Weiss, Tali; Honigstein, Danielle; Weissbrod, Aharon; Livne, Ethan; Gorodisky, Lior; Karagach, Shiri; Ravia, Aharon; Snitz, Kobi; Karawani, Diyala (2021-11-19).
"Sniffing the human body volatile hexadecanal blocks aggression in men but triggers aggression in women" .
Science Advances . 7 (47): eabg1530.
Bibcode :
2021SciA....7.1530M .
doi :
10.1126/sciadv.abg1530 .
ISSN
2375-2548 .
PMC
8604408 .
PMID
34797713 .
S2CID
244428241 .
^ Underwood, Emily (2021-11-19).
"Chemical emitted by babies could make men more docile, women more aggressive" .
Science .
doi :
10.1126/science.acx9685 .
S2CID
244449121 .