Heterogonesis describes the segregation of parental genomes into distinct cell lineages in the dividing
zygote.[1][2]
Fertilisation occurs when an
ovum fuses with a
sperm, forming a
zygote. Normally, the
genomes of the two parents assort into two
diploid bi-parental daughter cells. In a heterogoneic cell division, the genome of only one parent assorts into a single daughter cell following the formation of a tripolar (rather than the normal bipolar)
spindle apparatus.[3] Heterogonesis allows for chromosomal segregation to occur in a dispermic fertilisation which may subsequently result in
chimerism or
sesquizygosis.
The term heterogonesis was coined in 2016 by Destouni and Vermeesch who observed the phenomenon in
bovine zygotes.[1] The word is derived from the Greek meaning "different parental origin".