In 1966 he took-up a permanent academic post at the Institute of Psychiatry
under the leadership of Professor
Henry McIlwain, with whom Bachelard eventually culminated in joint authorship
the classic text "Biochemistry
and the Central Nervous System"[4] Bachelard's books also included "Brain Biochemistry"[5] and "Magnetic Resonance Spectroscopy and Imaging in Neurochemistry.",[6] and -as a co-editor- also "Neurochemistry : a practical approach"[7] In 1975 Herman was appointed to the Chair of Biochemistry in the University of Bath, and in 1979 undertook the Chair of Biochemistry at St. Thomas's Medical School, London. He was Chief Editor (Eastern Hemisphere) of the
Journal of Neurochemistry for five years, and also acted as the founding Secretary of the
European Society for Neurochemistry from 1976 until 1980 when he became its President and held that post until 1984.
Having developed an interest in non-invasive approaches to study brain metabolism Herman moved to Nottingham (UK), firstly as an external user at the newly formed MRC Biomedical NMR Centre at the National Institute for Medical Research, and then, in 1991, as a Research Professor in Residence at the Department of Physics of the University of Nottingham, from where he eventually retired in 1996.
Research
Most of Bachelard's research had the regulation of energy metabolism in the brain as a central theme, and involved invasive techniques in experimental animal preparations ranging from purified glycolytic-enzymes[8][9] to tissue-homogenates,[10] synaptosomes,[11][12][13] brain slices[14][15][16] and even anaesthetized live-animals.[17] Much of this work emphasized the brain's critical dependence on the availability of circulating glucose and oxygen, unveiling details of the molecular mechanisms involved in the regulation of carbohydrate metabolic pathways in the brain.[18][19] During his later years in Nottingham Bachelard participated actively in pioneerering studies in human volunteers on the application of "13-C
In vivo magnetic resonance spectroscopy" to estimate glucose-oxidation metabolic rates in visual cortex during intense light-stimulation.[20] A comprehensive list of most of his research articles can be found
here
^Bachelard, Henry McIlwain, Herman S. (1985). Biochemistry and the central nervous system (5th ed.). Edinburgh: Churchill Livingstone.
ISBN978-0443019616.{{
cite book}}: CS1 maint: multiple names: authors list (
link)
^Bachelard, H.S. (1981). Brain biochemistry (2nd ed.). London [etc.]: Chapman and Hall.
ISBN978-0412234705.
^Bachelard, Herman, ed. (1997). Magnetic Resonance Spectroscopy and Imaging in Neurochemistry. Boston, MA: Springer Verlag.
ISBN978-1461376880.
^Turner,..., ed. by A. J.; Bachelard,, H. S. (1997). Neurochemistry : a practical approach (2nd ed.). Oxford: IRL press at Oxford university press.
ISBN978-0199634392. {{
cite book}}: |first= has generic name (
help)CS1 maint: multiple names: authors list (
link)
^Heaton, GM; Bachelard, HS (November 1973). "The kinetic properties of hexose transport into synaptosomes from guinea pig cerebral cortex". Journal of Neurochemistry. 21 (5): 1099–108.
doi:
10.1111/j.1471-4159.1973.tb07564.x.
PMID4761699.
S2CID44814730.
^Park, IR; Thorn, MB; Bachelard, HS (September 1987). "Threshold requirements for oxygen in the release of acetylcholine from, and in the maintenance of the energy state in, rat brain synaptosomes". Journal of Neurochemistry. 49 (3): 781–8.
doi:
10.1111/j.1471-4159.1987.tb00961.x.
PMID3612124.
S2CID38225161.
^Cox, DW; Drower, J; Bachelard, HS (1985). "Effects of metabolic inhibitors on evoked activity and the energy state of hippocampal slices superfused in vitro". Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale. 57 (3): 464–70.
doi:
10.1007/BF00237833.
PMID2984037.
S2CID20377435.
^Obrenovitch, TP; Garofalo, O; Harris, RJ; Bordi, L; Ono, M; Momma, F; Bachelard, HS; Symon, L (December 1988). "Brain tissue concentrations of ATP, phosphocreatine, lactate, and tissue pH in relation to reduced cerebral blood flow following experimental acute middle cerebral artery occlusion". Journal of Cerebral Blood Flow and Metabolism. 8 (6): 866–74.
doi:
10.1038/jcbfm.1988.144.
PMID3192651.
S2CID36726218.