She leads the imaging research group in
psychiatry at the University of Edinburgh which has extensive links with several international consortia including the
Psychiatric Genomics Consortia, IMAGEMEND and ENIGMA. The group focuses on how causal factors (genetic and environmental) contribute to conditions through their impact on
brain structure and function using large population-based data resources where available, and identifying how brain structure and function mediate effects on behaviour.
Selected publications
A Phenome-Wide Association and Mendelian Randomisation Study of Polygenic Risk for Depression in UK Biobank Shen X, et al. Nature Communications, 2020 11 (1)[9]
The
neurobiology of personal control during reward learning and its relationship to mood. L Romaniuk et al. & HC Whalley. Biological Psychiatry:
Cognitive Neuroscience and Neuroimaging, 2019 4 (2), 190-199[10]
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions DM Howard, et al. Nature neuroscience, 2019 22 (3), 343[11]
Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in the UK Biobank. X Shen et al. & HC Whalley. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2018 3 (10), 878-886[12]
Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived
Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank. MC Barbu et al. & HC Whalley. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2018 4 (1), 91-100[13]
Longitudinal differences in white matter integrity in youth at high familial risk for
bipolar disorder.R Ganzola et al. & HC Whalley. Bipolar disorders, 2017 19 (3), 158-167[14]
Cognitive biases predict symptoms of
depression,
anxiety and wellbeing above and beyond neuroticism in adolescence. EM Smith, S Reynolds, F Orchard, HC Whalley*, SWY Chan*. Journal of affective disorders, 2018 241, 446-453[15]
Deactivation in
anterior cingulate cortex during
facial processing in young individuals with high familial risk and early development of depression: f MRI findings from the ...SWY Chan et al. & HC Whalley. Journal of Child Psychology and Psychiatry 57 (11), 1277-1286[16]
Dissection of
major depressive disorder using polygenic risk scores for
schizophrenia in two independent cohorts. HC Whalley et al. Translational psychiatry 6 (11), e938[17]