From Wikipedia, the free encyclopedia
Chemical compound
Harmol is a
chemical compound classified as a
β-carboline.
[1]
[2]
[3] It is readily formed
in vivo in humans by O-demethylation of
harmine.
[4]
See also
References
-
^ Abe A, Kokuba H (2013).
"Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of survivin". Oncol Rep. 29 (4): 1333–42.
doi:
10.3892/or.2013.2242.
PMID
23338618.
-
^ El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO (2012).
"Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol". Toxicol Lett. 208 (1): 51–61.
doi:
10.1016/j.toxlet.2011.09.030.
PMC
3263333.
PMID
22001777.
-
^ Abe A, Yamada H, Moriya S, Miyazawa K (2011).
"The β-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells". Biol Pharm Bull. 34 (8): 1264–72.
doi:
10.1248/bpb.34.1264.
PMID
21804216.
-
^ Morales-Garcia JA, de la Fuenta Revenga M, Alonso-Gil S, Rodriguez-Franco MI, Feiding A, Perez-Castillo A, Riba J (2017).
"The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro". Sci. Rep. 7 (1): 5309.
Bibcode:
2017NatSR...7.5309M.
doi:
10.1038/s41598-017-05407-9.
PMC
5509699.
PMID
28706205.