From Wikipedia, the free encyclopedia
Protein-coding gene in humans
Homeobox protein Hox-A10 is a
protein that in humans is encoded by the HOXA10
gene .
[5]
[6]
[7]
Function
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.
[7]
Downregulation of HOXA10 is observed in the human and
baboon decidua after implantation and this downregulation promotes
trophoblast invasion by activating
STAT3 .
[8]
Interactions
Homeobox A10 has been shown to
interact with
PTPN6 .
[9]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000253293 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000000938 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics . 7 (3): 460.
doi :
10.1016/0888-7543(90)90186-X .
PMID
1973146 .
^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell . 71 (4): 551–3.
doi :
10.1016/0092-8674(92)90588-4 .
PMID
1358459 .
S2CID
13370372 .
^
a
b
"Entrez Gene: HOXA10 homeobox A10" .
^ Godbole, Geeta; Suman, Pankaj; Malik, Ankita; Galvankar, Mosami; Joshi, Niraj; Fazleabas, Asgi; Gupta, Satish; Modi, Deepak (2017).
"Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion" . Endocrinology . 158 (8): 2618–2633.
doi :
10.1210/en.2017-00032 .
PMC
6283436 .
PMID
28520923 .
^ Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R (Sep 2002).
"SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells" . The Journal of Biological Chemistry . 277 (39): 36878–88.
doi :
10.1074/jbc.M203917200 .
PMID
12145285 .
Further reading
Eun Kwon H, Taylor HS (Dec 2004). "The role of HOX genes in human implantation". Annals of the New York Academy of Sciences . 1034 (1): 1–18.
Bibcode :
2004NYASA1034....1E .
doi :
10.1196/annals.1335.001 .
PMID
15731295 .
S2CID
41501204 .
Lowney P, Corral J, Detmer K, LeBeau MM, Deaven L, Lawrence HJ, Largman C (Jun 1991).
"A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells" . Nucleic Acids Research . 19 (12): 3443–9.
doi :
10.1093/nar/19.12.3443 .
PMC
328346 .
PMID
1676505 .
Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ (Nov 1989).
"Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines" . Proceedings of the National Academy of Sciences of the United States of America . 86 (21): 8536–40.
Bibcode :
1989PNAS...86.8536S .
doi :
10.1073/pnas.86.21.8536 .
PMC
298317 .
PMID
2573064 .
Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989).
"The human HOX gene family" . Nucleic Acids Research . 17 (24): 10385–402.
doi :
10.1093/nar/17.24.10385 .
PMC
335308 .
PMID
2574852 .
Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK (Dec 1994).
"Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells" . Proceedings of the National Academy of Sciences of the United States of America . 91 (25): 12223–7.
Bibcode :
1994PNAS...9112223S .
doi :
10.1073/pnas.91.25.12223 .
PMC
45409 .
PMID
7527557 .
Lawrence HJ, Sauvageau G, Ahmadi N, Lopez AR, LeBeau MM, Link M, Humphries K, Largman C (Oct 1995). "Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells". Experimental Hematology . 23 (11): 1160–6.
PMID
7556525 .
Satokata I, Benson G, Maas R (Mar 1995). "Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice". Nature . 374 (6521): 460–3.
Bibcode :
1995Natur.374..460S .
doi :
10.1038/374460a0 .
PMID
7700356 .
S2CID
4337017 .
Castronovo V, Kusaka M, Chariot A, Gielen J, Sobel M (Jan 1994).
"Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype" . Biochemical Pharmacology . 47 (1): 137–43.
doi :
10.1016/0006-2952(94)90447-2 .
PMID
7906121 .
Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics . 73 (1–2): 114–5.
doi :
10.1159/000134320 .
PMID
8646877 .
Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK (Jan 1997).
"Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia" . Molecular and Cellular Biology . 17 (1): 495–505.
doi :
10.1128/mcb.17.1.495 .
PMC
231774 .
PMID
8972230 .
Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997).
"AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins" . Molecular and Cellular Biology . 17 (11): 6448–58.
doi :
10.1128/MCB.17.11.6448 .
PMC
232497 .
PMID
9343407 .
Taylor HS, Vanden Heuvel GB, Igarashi P (Dec 1997).
"A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes" . Biology of Reproduction . 57 (6): 1338–45.
doi :
10.1095/biolreprod57.6.1338 .
PMID
9408238 .
Taylor HS, Arici A, Olive D, Igarashi P (Apr 1998).
"HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium" . The Journal of Clinical Investigation . 101 (7): 1379–84.
doi :
10.1172/JCI1057 .
PMC
508715 .
PMID
9525980 .
Kawagoe H, Humphries RK, Blair A, Sutherland HJ, Hogge DE (May 1999).
"Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells" . Leukemia . 13 (5): 687–98.
doi :
10.1038/sj/leu/2401410 .
PMID
10374871 .
Eklund EA, Jalava A, Kakar R (Jun 2000).
"Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines" . The Journal of Biological Chemistry . 275 (26): 20117–26.
doi :
10.1074/jbc.M907915199 .
PMID
10766757 .
Buske C, Feuring-Buske M, Antonchuk J, Rosten P, Hogge DE, Eaves CJ, Humphries RK (Apr 2001).
"Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo" . Blood . 97 (8): 2286–92.
doi :
10.1182/blood.V97.8.2286 .
PMID
11290589 .
Cermik D, Karaca M, Taylor HS (Jul 2001).
"HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract" . The Journal of Clinical Endocrinology and Metabolism . 86 (7): 3387–92.
doi :
10.1210/jcem.86.7.7675 .
PMID
11443215 .
S2CID
23775476 .
Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001).
"The HOX homeodomain proteins block CBP histone acetyltransferase activity" . Molecular and Cellular Biology . 21 (21): 7509–22.
doi :
10.1128/MCB.21.21.7509-7522.2001 .
PMC
99922 .
PMID
11585930 .
[1]
[2]
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors