HORMA domain | |||||||||
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![]() crystal structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20. | |||||||||
Identifiers | |||||||||
Symbol | HORMA | ||||||||
Pfam | PF02301 | ||||||||
InterPro | IPR003511 | ||||||||
SCOP2 | 1duj / SCOPe / SUPFAM | ||||||||
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In molecular biology, the HORMA domain (named after the Hop1p, Rev7p and MAD2 proteins) is a protein domain that has been suggested to recognise chromatin states resulting from DNA adducts, double stranded breaks or non-attachment to the spindle and act as an adaptor that recruits other proteins. Hop1 is a meiosis-specific protein, Rev7 is required for DNA damage induced mutagenesis, and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity. [1] [2]
Humans proteins containing this domain include: