The HIV Prevention Trials Network (HPTN) is a worldwide collaborative clinical trials network that brings together investigators, ethicists, community and other partners to develop and test the safety and efficacy of interventions designed to prevent the acquisition and transmission of
HIV. HPTN studies evaluate new HIV prevention interventions and strategies in populations and geographical regions that bear a disproportionate burden of infection. The HPTN is committed to the highest ethical standards for its clinical trials and recognizes the importance of community engagement in all phases of the research process.
The HPTN is dedicated to the discovery and development of new and innovative research strategies to reduce the acquisition and transmission of
HIV.[citation needed]
Leadership
The HPTN leadership group is a subset of the Executive Committee (EC). The EC includes investigators from the Clinical Trials Units (CTUs), the Leadership and Operations Center (LOC), the Statistical and Data Management Center (SDMC), the Laboratory Center (LC), Community representatives,
National Institutes of Health (NIH) representatives, and other individuals with expertise in HPTN scientific research areas.[citation needed]
The EC, under the direction of HPTN Principal Investigators (PIs) Dr. Myron Cohen,[when?] and Dr. Wafaa El-Sadr[when?] in conjunction with the NIH, sets the research priorities of the HPTN and directs its scientific agenda.
Network groups and committees
The HPTN is a global network of investigators from Clinical Trials Units (CTUs), Leadership and Operations Center (LOC) which includes recognized experts in
HIV prevention, leadership partners from the network Laboratory Center (LC) and Statistical and Data Management Center (SDMC) and various working groups (WGs) and committees charged with the scientific management and operational support of the network.[citation needed]
The EC Chair recommends, and the full EC approves, chair(s) and membership of the HPTN committees. Committee members serve for the duration of the cooperative agreement, and chairs serve three-year terms unless otherwise specified. Terms of committee chairs may be extended with the approval of the EC Chair. In addition to the scientific committees and working groups, there are four key standing Network oversight and operations committees: Science Review Committee (SRC), Study Monitoring Committee (SMC), Manuscript Review Committee (MRC), and Performance Evaluation Committee (PEC). [2]
Research agenda
The HPTN research agenda focuses on the following four priority areas:[3]
Identifying novel antiretroviral (ARV)-based methods and delivery systems for HIV prevention
Developing multi-purpose technologies for HIV prevention as well as for contraception and prevention of other sexually transmitted infections
Evaluating broadly neutralizing antibodies alone or in a combination that prevent HIV acquisition, in collaboration with the HIV Vaccine Trials Network
Designing and conducting population-specific integrated strategy studies that combine biomedical, socio-behavioral, and structural interventions for HIV prevention to maximize their effectiveness
Pre-exposure prophylaxis (PrEP) strategies
Antiviral Drugs
HPTN 084-01 (The LIFT Study) is a clinical trial examining whether injectable cabotegravir (CAB) for
pre-exposure prophylaxis (PrEP) is safe and acceptable for adolescent females (assigned female at birth).[4]
HPTN 084 is a phase III study comparing the efficacy and safety of long-acting injectable
cabotegravir (CAB-LA) to
Truvada® for prevention of HIV acquisition in women in
Botswana,
Kenya,
Malawi,
South Africa,
Swaziland,
Uganda and
Zimbabwe.[5] Data from the HPTN 084 clinical trial indicate that a
pre-exposure prophylaxis (PrEP) regimen of long-acting cabotegravir (CAB LA) injections once every eight weeks was safe and superior to daily oral tenofovir/emtricitabine (FTC/TDF) for HIV prevention among
cisgender women in sub-Saharan Africa.[6]
HPTN 083-02 is a clinical trial examining factors influencing adherence to injectable PrEP and retention in an injectable PrEP research study.[7]
HPTN 083 is a phase IIb/III study comparing the efficacy and safety of long-acting injectable
cabotegravir (CAB-LA) to
Truvada® for prevention of HIV acquisition in
cisgender MSM and
transgender women who have sex with men in
Argentina,
Brazil,
Peru,
South Africa,
Thailand, the
United States and
Vietnam.[8] Data from the HPTN 083 clinical trial showed that a pre-exposure prophylaxis (PrEP) regimen containing long-acting cabotegravir (CAB LA) injected once every eight weeks was superior to daily oral tenofovir/emtricitabine (TDF/FTC) for HIV prevention among cisgender men and transgender women who have sex with men.[9]
HPTN 082 was a phase IV sub-Saharan-based research study designed to assess the number of and characteristics of young women who accept versus decline
pre-exposure prophylaxis (PrEP) at enrollment. The study compared adherence to PrEP between women who are randomized to receive standard adherence support and those receiving enhanced adherence support.[10] HPTN 082 data show
pre-exposure prophylaxis (PrEP) use was high but waned after three months among the young African women enrolled in the study.[11]
HPTN 077 was a phase IIa study helping determine whether injectable
cabotegravir could be used for
PrEP in people at greater risk of acquiring
HIV.[12] The study showed that cabotegravir was safe and well-tolerated.
HPTN 076 was a phase II study designed to find out if a new form of the drug
rilpivirine is safe and acceptable for use as
HIVpre-exposure prophylaxis (PrEP).[13] Study findings demonstrated long-acting rilpivirine is safe. Overall there was no difference in the number and type of side effects (adverse events) between the study group receiving long-acting rilpivirine and the study group receiving placebo.
HPTN 073 was a phase IV demonstration study see if Black men who have sex with men (BMSM) are willing to use Truvada®, a daily pill for
pre-exposure prophylaxis (PrEP).[14] Study findings, based on participant self-report, showed high uptake of PrEP for prevention of HIV infection among BMSM in the U.S. with the use of a novel coordinated counseling and care approach resulting in findings suggestive of a lower rate of HIV infection.
Data from
HPTN 083 and
HPTN 084 helped provide important information for the December 20, 2021 decision by the
U.S. Food and Drug Administration (FDA) to approve
ViiV Healthcare’s long-acting cabotegravir (CAB-LA) injections for the prevention of HIV. Sponsored and co-funded by the
National Institute of Allergy and Infectious Diseases (NIAID), part of the
National Institutes of Health (NIH), these studies showed that CAB-LA injected once every eight weeks was superior to daily oral tenofovir/emtricitabine (TDF/FTC) for HIV prevention among cisgender men and transgender women who have sex with men (HPTN 083) and cisgender women (HPTN 084). Both studies also demonstrated that CAB-LA was well-tolerated, offering a new and important pre-exposure prophylaxis (PrEP) option for individuals at risk for HIV infection. ViiV Healthcare will market CAB-LA for PrEP under the brand name
Apretude.
Monoclonal Antibodies
The HPTN and the
HIV Vaccine Trials Network (HVTN) are studying
monoclonal antibodies (mAbs) that may protect people from
HIV infection. These studies will guide the development of new ways to prevent
HIV. They will also guide future vaccine development that could help to end
HIV.[18]
HVTN 143/HPTN 109 is a phase 1 clinical trial to evaluate the safety, tolerability, pharmacokinetics and tolerability of combinations of monoclonal antibodies VRC01.23LS, PGT121.414.LS, and PGDM1400LS administered via intravenous infusion in adults without HIV.
HVTN 140/HPTN 101 is a phase 1 dose-escalation clinical trial to evaluate the safety, tolerability, and pharmacokinetics of PGDM1400LS alone and in combination with VRC07- 523LS and PGT121.414.LS in healthy, HIV-uninfected adult participants.[19]
HVTN 136/HPTN 092 is a phase 1 dose-escalation clinical trial to evaluate the safety, tolerability, pharmacokinetics, and antiviral activity of the
monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS via intravenous infusion or via subcutaneous injections in healthy, HIV-uninfected adult participants.[22]
HVTN 130/HPTN 089 is a phase I clinical trial to evaluate the safety, tolerability, pharmacokinetics, and antiviral activity of combinations of
monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered via intravenous infusion in healthy, HIV-uninfected adult participants[23]
HVTN 127/HPTN 087 is a phase I study evaluating the safety and serum concentrations of a human
monoclonal antibody, VRC-HIVMAB075-00-AB (VRC07-523LS), administered in multiple doses and routes to healthy,
HIV-uninfected adults in
Switzerland and the
United States.[24]
Antibody Mediated Prevention (AMP), are two phase IIb studies evaluating the safety and efficacy of VRC01, a broadly neutralizing
monoclonal antibody (bnAb), in reducing acquisition of
HIV-1 infection among cisgender men and transgender persons (TG) who have sex with men in
Brazil,
Peru,
Switzerland and the
United States (
HVTN 704/HPTN 085), and sexually active cisgender women in
sub-Saharan Africa (
HVTN 703/HPTN 081). Findings from the proof-of-concept AMP studies demonstrated VRC01 was effective at preventing the acquisition of HIV strains that were sensitive to the bnAb. This was assessed by a laboratory test that measures a virus’ susceptibility to neutralization by an antibody.[25]
Integrated strategies
HPTN 096 is a study assessing an integrated, HIV status-neutral, population-based approach designed to reduce HIV incidence among Black MSM in the U.S. South by increasing
HIV testing,
pre-exposure prophylaxis (PrEP) use among Black MSM living without
HIV, and viral suppression rates among Black MSM living with
HIV.[26]
HPTN 094 or “INTEGRA” is a vanguard study to determine the efficacy of using a mobile health unit to provide integrated health services - particularly medication for
opioid use disorder (OUD) and medication for HIV treatment or prevention - to people with OUD who inject drugs in five U.S. cities.[27]
HPTN 091 is a study assessing the feasibility, acceptability, preliminary impact of a multi-component strategy that provides HIV prevention services, gender-affirming hormone therapy, and peer health navigation to improve
pre-exposure prophylaxis (PrEP) uptake and adherence among
transgender women in the Americas.[28]
HPTN 078 was a US-based research study designed to develop and determine the effectiveness of a combined
HIV prevention strategy that includes a method to identify, recruit, and link
men who have sex with men (MSM) to
HIV care and an intervention to help HIV-infected MSM achieve and maintain viral suppression (low level of
HIV in the body).[29] Findings from HPTN 078 show engaging disenfranchised
men who have sex with men (MSM) living with
HIV in the U.S. is possible, but the best way to help them achieve and maintain viral suppression is not yet known.[30]
HPTN 075 was an observational study aimed to evaluate the feasibility of
HIV prevention research among
men who have sex with men and
transgender women in three countries in
sub-Saharan Africa. Findings from the study showed participants were at an alarming risk for getting
HIV. The incidence among study participants was substantially higher than the estimated incidence among heterosexual men and women in the general population in the same countries.[31]
HPTN 074 was a phase III study aimed to determine the feasibility of a future trial that would assess whether an integrated intervention combining psychosocial counseling and supported referrals for
antiretroviral therapy (ART) at any
CD4 cell count and substance use treatment for
HIV-infected people who inject drugs (PWID) would reduce
HIV transmission to
HIV-uninfected injection partners, as compared to routine care dictated by national guidelines for
HIV-infected PWID. At 52 weeks from enrollment, participants in the intervention arm nearly doubled their antiretroviral therapy usage, viral suppression and medication-assisted treatment usage compared to the standard of care arm. Mortality was also reduced by more than half with the intervention.[32]
HPTN 071 Population Effects of Antiretroviral Therapy to Reduce HIV Transmission (PopART) was a research study that examined the impact of a package of
HIV prevention interventions on community-level
HIV incidence. The prevention interventions included universal voluntary
HIV counseling and testing provided at household level, linkage of
HIV infected individuals to care and early initiation of
antiretroviral therapy (ART) for all those testing
HIV-positive. The study was conducted in 21 communities in the Western Cape of
South Africa, and in
Zambia. Findings show delivery of an HIV prevention strategy that includes offering in-home HIV testing to everyone, with immediate referral to HIV care, and treatment for people living with HIV based on prevailing in-country guidelines, can substantially reduce new HIV infections.[33] Findings from HPTN 071 (PopART) show delivery of an HIV prevention strategy that includes offering in-home
HIV testing to everyone, with immediate referral to
HIV care, and treatment for people living with
HIV based on prevailing in-country guidelines, can substantially reduce new
HIV infections.[34] According to projections from mathematical modelling and cost-effectiveness analyses, continuation of community-wide HIV testing and prompt initiation of treatment as delivered in the HPTN 071 (PopART) study in South Africa and Zambia could lead to substantial reductions in new HIV cases, be cost-effective, and help to achieve the
UNAIDS 2030 targets.[35]
Scholars program
The HPTN Scholars Program seeks to provide scholar recipients with the knowledge, skills and connections to further their careers as independent investigators in the
HIV prevention research field.[36] Domestic and international scientists from groups under-represented in HIV prevention research are encouraged to apply. Successful domestic investigator applicants will have received their terminal degree (MD, PhD, etc.). For international investigators, current MD, PhD, and MBChB students may apply, along with individuals who already graduated with their terminal degree.[citation needed]
Scholars:
Develop a research project using data from a completed or ongoing HPTN
HIV prevention study and complete their scholarship project within the program cycle
Present the findings of their project at the HPTN Annual Meeting and submit a manuscript at the end of the scholarship cycle
Become knowledgeable of the process of doing research in NIH-funded
HIV networks, and have the opportunity to build their research networks within the context of the HPTN
Scholars are provided funding to cover a portion of their time (typically ~ 10-30%) and expenses including travel and research materials/supplies. Successful applicants will be funded for 18 months, subject to certain restrictions. The HPTN Scholars Program is funded through a supplement from the
National Institute of Allergy and Infectious Diseases and the
National Institute on Drug Abuse.[37]
Community program
Community participation and engagement are critical in the conduct of scientific research. There is mutual benefit to communities and researchers when both parties work together throughout the scientific research process. In the HPTN, community participation occurs throughout the network, community and site levels through various mechanisms that include representation on the Ethics Working Group, the Science Review Committee and protocol teams.[38]