From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Hedgehog acyltransferase (HHAT), also called skinny hedgehog homology in humans, is a human
gene.
[1]
[2]
The HHAT gene encodes an
enzyme that catalyzes
N-terminal
palmitoylation of
sonic hedgehog. Mutations in HHAT produce a
phenotype that is similar to loss of hedgehog function. Finally the HHAT protein shares a short but significant sequence similarity to
membrane-bound O-acyltransferases.
[3]
References
-
^ Kawakami Y, Wang X, Shofuda T, Sumimoto H, Tupesis J, Fitzgerald E, Rosenberg S (February 2001).
"Isolation of a new melanoma antigen, MART-2, containing a mutated epitope recognized by autologous tumor-infiltrating T lymphocytes". J. Immunol. 166 (4): 2871–7.
doi:
10.4049/jimmunol.166.4.2871.
PMID
11160356.
-
^
"OMIM Entry - * 605743 - HEDGEHOG ACYLTRANSFERASE; HHAT". www.omim.org. Retrieved 2017-02-20.
-
^ Chamoun Z, Mann RK, Nellen D, von Kessler DP, Bellotto M, Beachy PA, Basler K (September 2001).
"Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal". Science. 293 (5537): 2080–4.
Bibcode:
2001Sci...293.2080C.
doi:
10.1126/science.1064437.
PMID
11486055.
S2CID
39594965.
External links