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Strain of Middle East respiratory syndrome-related coronavirus
MERS coronavirus EMC/2012 (MERS coronavirus Erasmus Medical Center/2012 ) is a
strain of
coronavirus isolated from the
sputum of the first person to become infected with what was later named
Middle East respiratory syndrome–related coronavirus (MERS-CoV ), a virus that causes
Middle East respiratory syndrome (MERS).
[1]
[2]
[3]
[4]
Natural reservoir
An investigation of bat roosts in
Bisha , the hometown of the index patient, by the
Saudi Ministry of Health discovered an
Egyptian tomb bat in a large roost close to the
index patient 's home.
Phylogenetic analysis showed a 100% match between the virus isolated from the bat and MERS coronavirus EMC/2012 isolated from the index patient.
[5]
Virology
MERS coronavirus EMC/2012 is the sixth coronavirus known to infect humans and the first human virus within
betacoronavirus lineage C . It is a new
genotype which is related to bat
coronaviruses , specifically an Egyptian tomb bat, and is not the same beta-CoV as the
SARS-CoV , but is distantly related.
[3]
[6]
See also
References
^ Zaki, AM; van Boheemen, S; Bestebroer, TM; Osterhaus, AD; Fouchier, RA (2012).
"Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia" . N Engl J Med . 367 (19): 1814–20.
doi :
10.1056/nejmoa1211721 .
PMID
23075143 .
^ Holmes, KV; Dominguez, SR (January 2013).
"The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia" . mBio . 4 (1): e00548–12.
doi :
10.1128/mBio.00548-12 .
PMC
3546555 .
PMID
23300251 .
^
a
b Van Boheemen, S; de Graaf, M; Lauber, C; Bestebroer, TM; Raj, VS; Zaki, AM; Osterhaus, AD; Haagmans, BL; Gorbalenya, AE; Snijder, EJ; Fouchier, RA (November 2012).
"Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans" . mBio . 3 (6): 6.
doi :
10.1128/mBio.00473-12 .
PMC
3509437 .
PMID
23170002 .
^ Chan, JF; Li, KS; To, KK; Cheng, VC; Chen, H; Yuen, KY (25 March 2013).
"Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?" . J Infect . 65 (6): 477–89.
doi :
10.1016/j.jinf.2012.10.002 .
PMC
7112628 .
PMID
23072791 .
^ Memish, Ziad A.; Mishra, Nischay; Olival, Kevin J.; Fagbo, Shamsudeen F.; Kapoor, Vishal; Epstein, Jonathan H.; Alhakeem, Rafat; Durosinloun, Abdulkareem; Al Asmari, Mushabab; Islam, Ariful; Kapoor, Amit; Briese, Thomas; Daszak, Peter; Al Rabeeah, Abdullah A.; Lipkin, W. Ian (2013).
"Middle East Respiratory Syndrome Coronavirus in Bats, Saudi Arabia" . Emerging Infectious Diseases . 19 (11): 1819–23.
doi :
10.3201/eid1911.131172 .
PMC
3837665 .
PMID
24206838 .
^ Chan, JF; Li, KS; To, KK; Cheng, VC; Chen, H; Yuen, KY (December 2012).
"Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?" . J Infect . 65 (6): 477–89.
doi :
10.1016/j.jinf.2012.10.002 .
PMC
7112628 .
PMID
23072791 .