Guillermina Lozano | |
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Alma mater |
Pan American University (BSc) Rutgers University (PhD) |
Awards |
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Scientific career | |
Institutions | University of Texas MD Anderson Cancer Center |
Thesis | Isolation, characterization and analysis of the gene encoding the Alpha 2 type IX collagen polypeptide (1986) |
Guillermina 'Gigi' Lozano is an American geneticist. She is a Professor and Hubert L. Olive Stringer Distinguished Chair in Oncology in Honor of Sue Gribble Stringer at the University of Texas MD Anderson Cancer Center, Houston, Texas. Lozano is recognised for her studies of the p53 tumour suppressor pathway, characterising the protein as a regulator of gene expression ( transcription factor) and that is disturbed in many cancers. She was the first to show that p53 helps turn on other genes and pointed out that changes to this gene are seen in over 90% of cancers. She also found out how the Mdm2 and Mdm4 proteins work in the body, especially in stopping cancer and controlling p53. This research suggests that blocking Mdm2/4 could be a new way to treat cancer. [1] [2]
Lozano was born in East Chicago, Indiana, the daughter of Mexican immigrants. She attended a private Catholic high school, Bishop Noll, up until her senior year, when her family moved to McAllen, Texas. [3]
Lozano completed a Bachelor of Science in biology and mathematics, graduating Magna Cum Laude, at Pan American University (now University of Texas Rio Grande Valley) in 1979. She earned a doctor of philosophy in biochemistry from Rutgers University and University of Medicine and Dentistry of New Jersey in 1986. [4] Lozano's dissertation was titled Isolation, characterization and analysis of the gene encoding the Alpha 2 type IX collagen polypeptide. [5] She completed postgraduate training in molecular biology at Princeton University from 1985 to 1987. [4]
Lozano is Professor and Chair of the Department of Genetics [6] at University of Texas MD Anderson Cancer Center. She is also a professor at University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences. [4]
Lozano is recognised for her studies of the p53 [7] tumour suppressor pathway, from characterising p53 as a transcriptional activator [8] to revealing the importance of two inhibitors of p53, Mdm2 and Mdm4. Her lab has generated dozens of mouse models of p53 to explore effects of mutations in this tumor-suppressing protein on tumorogeneis. [9]
Lozano is a member of the National Academy of Sciences, [10] National Academy of Medicine, [11] Academy of Medicine, Engineering and Science of Texas. [4]
Awards:
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