From Wikipedia, the free encyclopedia
Swiss-Dutch molecular biologist
Françoise Gisou van der Goot (born 19 September 1964 in
Tehran )
[2] is a Swiss-Dutch
cell biologist .
[1]
[3] She is a professor and the Vice President for Responsible Transformation at
EPFL (École Polytechnique Fédérale de Lausanne) .
[4]
Career
Gisou van der Goot studied
engineering at the
École Centrale de Paris . She pursued a
PhD in
molecular biophysics at the
Saclay Nuclear Research Centre (
Pierre and Marie Curie University ).
[5] After her PhD, she was a
postdoctoral researcher at the
European Molecular Biology Laboratory (EMBL) in
Heidelberg . In 1994 she worked as a group leader in the Department of Biochemistry of the
University of Geneva and, subsequently, from 2001 as
associate professor in the department of
microbiology and
molecular medicine . Since 2006, she has been full professor of
molecular and
cellular microbiology at the School of Life Sciences of
EPFL ,
[6]
[7] where she was also dean until 2020.
[8] In September 2020, she was appointed Vice President for Responsible Transformation at
EPFL for a term starting in 2021.
[4]
Research
Gisou van der Goot leads the Laboratory of Cell and Membrane Biology at the
School of Life Sciences of the
École Polytechnique Fédérale de Lausanne (EPFL).
[9] Her laboratory studies various aspects of
cellular and intracellular membrane dynamics. Notably, it aims to better understand the way protein
palmitoylation regulates
endoplasmic reticulum function and
protein trafficking ,
[10] the mechanisms which allow bacterial proteins such as the
anthrax toxin to penetrate target cells,
[11] and the molecular mechanisms leading to
juvenile hyaline fibromatosis , a rare and debilitating
genetic disorder .
[12] In the context of the
COVID-19 pandemic , Gisou van der Goot declared to have dedicated part of her laboratory to study
SARS-CoV-2 .
[13]
Awards and honors
Gisou van der Goot obtained a
European Molecular Biology Organization (EMBO) Young Investigator award
[14] in 2001 and an
Howard Hughes International Scholar award in 2005. In 2009, she received the Leenaards Foundation Research Prize
[15] and the
Marcel Benoist Prize .
[16] The latter two prizes were awarded for her contributions to the
biochemistry of the
bacterial toxin of the
anthrax
pathogen at the host
cell membrane . In 2020, she was awarded the
Suffrage Science award .
[17]
She has been member of scientific boards such as the
Swiss National Science Foundation ,
[18] the
Swiss Science Council and the
European Research Council (ERC).
[6]
Selected works
Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; Adams, Christopher M.; Adams, Peter D.; Adeli, Khosrow; Adhihetty, Peter J.; Adler, Sharon G.; Agam, Galila; Agarwal, Rajesh; Aghi, Manish K.; Agnello, Maria; Agostinis, Patrizia; Aguilar, Patricia V.; Aguirre-Ghiso, Julio; Airoldi, Edoardo M.; Ait-Si-Ali, Slimane; Akematsu, Takahiko; Akporiaye, Emmanuel T.; Al-Rubeai, Mohamed; Albaiceta, Guillermo M.; Albanese, Chris; Albani, Diego; Albert, Matthew L.; Aldudo, Jesus; et al. (2016).
"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)" . Autophagy . 12 (1): 1–222.
doi :
10.1080/15548627.2015.1100356 .
PMC
4835977 .
PMID
26799652 .
Abrami, Laurence; Liu, Shihui; Cosson, Pierre; Leppla, Stephen H.; Van Der Goot, F. Gisou (2003).
"Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process" . Journal of Cell Biology . 160 (3): 321–328.
doi :
10.1083/jcb.200211018 .
PMC
2172673 .
PMID
12551953 .
Gurcel, Laure; Abrami, Laurence; Girardin, Stephen; Tschopp, Jurg; Van Der Goot, F. Gisou (2006).
"Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival" . Cell . 126 (6): 1135–1145.
doi :
10.1016/j.cell.2006.07.033 .
PMID
16990137 .
S2CID
616037 .
Pizarro-Cerdá, Javier; MéResse, StéPhane; Parton, Robert G.; Van Der Goot, Gisou; Sola-Landa, Alberto; Lopez-Goñi, Ignacio; Moreno, Edgardo; Gorvel, Jean-Pierre (1998).
"Brucella abortus Transits through the Autophagic Pathway and Replicates in the Endoplasmic Reticulum of Nonprofessional Phagocytes" . Infection and Immunity . 66 (12): 5711–5724.
doi :
10.1128/IAI.66.12.5711-5724.1998 .
PMC
108722 .
PMID
9826346 .
Van Der Goot, F. G.; González-Mañas, J. M.; Lakey, J. H.; Pattus, F. (1991). "A 'molten-globule' membrane-insertion intermediate of the pore-forming domain of colicin A". Nature . 354 (6352): 408–410.
Bibcode :
1991Natur.354..408V .
doi :
10.1038/354408a0 .
PMID
1956406 .
S2CID
4301346 .
Gruenberg, Jean; Van Der Goot, F. Gisou (2006). "Mechanisms of pathogen entry through the endosomal compartments". Nature Reviews Molecular Cell Biology . 7 (7): 495–504.
doi :
10.1038/nrm1959 .
PMID
16773132 .
S2CID
429568 .
Peraro, Matteo Dal; Van Der Goot, F. Gisou (2016). "Pore-forming toxins: Ancient, but never really out of fashion". Nature Reviews Microbiology . 14 (2): 77–92.
doi :
10.1038/nrmicro.2015.3 .
PMID
26639780 .
S2CID
6784199 .
Dupont, Nicolas; Lacas-Gervais, Sandra; Bertout, Julie; Paz, Irit; Freche, Barbara; Van Nhieu, Guy Tran; Van Der Goot, F. Gisou; Sansonetti, Philippe J.; Lafont, Frank (2009).
"Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy" . Cell Host & Microbe . 6 (2): 137–149.
doi :
10.1016/j.chom.2009.07.005 .
PMID
19683680 .
Personal life
Gisou van der Goot is married to Swiss biologist
Jean Gruenberg and has two children.[
citation needed ]
References
^
a
b
Gisou van der Goot publications indexed by
Google Scholar
^
"Françoise Gisou van der Goot reçoit le Prix Marcel Benoist 2009" . admin.ch . Retrieved 2020-08-01 .
^
Gisou van der Goot publications from
Europe PubMed Central
^
a
b
"Board appoints new members of the Executive Boards of ETH Zurich and EPFL | ETH-Board" . ethrat.ch . Archived from
the original on 2021-04-20. Retrieved 2020-09-25 .
^ ORCID.
"Gisou van der Goot (0000-0002-8522-274X)" . orcid.org . Retrieved 2021-01-20 .
^
a
b
"Gisou van der Goot" . people.epfl.ch . Retrieved 2020-07-29 .
^
"Van der Goot Lab ‐ EPFL" . Retrieved 2020-07-29 .
^ Evangelista, Sandy (2020-04-06).
" "The most important thing is staying in touch" " .
^
"van der Goot Lab – Laboratory of Cell and Membrane Biology" . epfl.ch . Retrieved 2020-08-13 .
^ Blaskovic, Sanja; Blanc, Mathieu; Goot, F. Gisou van der (2013).
"What does S-palmitoylation do to membrane proteins?" . The FEBS Journal . 280 (12): 2766–2774.
doi :
10.1111/febs.12263 .
ISSN
1742-4658 .
PMID
23551889 .
^ Abrami, Laurence; Liu, Shihui; Cosson, Pierre; Leppla, Stephen H.; van der Goot, F. Gisou (2003).
"Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process" . Journal of Cell Biology . 160 (3): 321–328.
doi :
10.1083/jcb.200211018 .
ISSN
0021-9525 .
PMC
2172673 .
PMID
12551953 .
^ Deuquet, Julie; Lausch, Ekkehart; Guex, Nicolas; Abrami, Laurence; Salvi, Suzanne; Lakkaraju, Asvin; Ramirez, Maria Celeste M.; Martignetti, John A.; Rokicki, Dariusz; Bonafe, Luisa; Superti-Furga, Andrea (2011).
"Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors" . EMBO Molecular Medicine . 3 (4): 208–221.
doi :
10.1002/emmm.201100124 .
ISSN
1757-4676 .
PMC
3377065 .
PMID
21328543 .
^
"Gisou van der Goot, de l'anthrax au Covid-19" . Le Temps (in French). 2020-07-02.
ISSN
1423-3967 . Retrieved 2020-08-13 .
^
"Find an EMBO Young Investigator / EMBO Installation Grantee / EMBO Global Investigator" . yip-search.embo.org . Retrieved 2020-07-29 .
^
"Etude des mécanismes amenant des pathogènes à être mortels pour l'homme" . Fondation Leenaards - Favoriser la dynamique créatrice (in French). Retrieved 2020-07-29 .
^
"Past laureates – Marcel Benoist Foundation" . marcel-benoist.ch . Retrieved 2020-08-01 .
^ Arthur, Sophie (2020-10-22).
"Life Sciences Awardee 2020: Professor Gisou van der Goot" . suffragescience . Retrieved 2020-10-23 .
^
"Former SSC members" . swir.ch . Retrieved 2020-07-29 .
External links
International National Academics Other