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Medical therapy against aging
This article needs to be updated . Please help update this article to reflect recent events or newly available information. (June 2023 )
A geroprotector is a
senotherapeutic that aims to affect the root cause of aging and age-related diseases, and thus prolong the
life span of animals.
[1]
[2] Some possible geroprotectors include
melatonin ,
[3]
carnosine ,
[4]
metformin ,
[5]
rapamycin ,
[6]
nicotinamide mononucleotide (NMN)
[7] and
delta sleep-inducing peptide .
[8]
See also
References
^ Alexey Moskalev, Elizaveta Chernyagina, Anna Kudryavtseva & Mikhail Shaposhnikov (2017).
"Geroprotectors: A Unified Concept and Screening Approaches" . Aging and Disease . 8 (3): 354–363.
doi :
10.14336/AD.2016.1022 .
PMC
5440114 .
PMID
28580190 . {{
cite journal }}
: CS1 maint: multiple names: authors list (
link )
^ Alexey Moskalev, Elizaveta Chernyagina,
João Pedro de Magalhães &
Alex Zhavoronkov (2015).
"Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease" .
Aging . 7 (9): 616–628.
doi :
10.18632/aging.100799 .
PMC
4600621 .
PMID
26342919 . {{
cite journal }}
: CS1 maint: multiple names: authors list (
link )
^ Anisimov, VN; Popovich, IG; Zabezhinski, MA; Anisimov, SV; Vesnushkin, GM; Vinogradova, IA (2006).
"Melatonin as antioxidant, geroprotector and anticarcinogen" . Biochimica et Biophysica Acta (BBA) - Bioenergetics . 1757 (5–6): 573–89.
doi :
10.1016/j.bbabio.2006.03.012 .
PMID
16678784 .
^ Boldyrev, AA; Stvolinsky, SL; Fedorova, TN; Suslina, ZA (2010). "Carnosine as a natural antioxidant and geroprotector: From molecular mechanisms to clinical trials". Rejuvenation Research . 13 (2–3): 156–8.
doi :
10.1089/rej.2009.0923 .
PMID
20017611 .
^ Bulterijs, S (2011). "Metformin As a Geroprotector". Rejuvenation Research . 14 (5): 469–82.
doi :
10.1089/rej.2011.1153 .
PMID
21882902 .
S2CID
40645408 .
^ Dumas, Sabrina N; Lamming, Dudley W (2020-01-01).
"Next Generation Strategies for Geroprotection via mTORC1 Inhibition" . The Journals of Gerontology: Series A . 75 (1): 14–23.
doi :
10.1093/gerona/glz056 .
ISSN
1079-5006 .
PMC
6909887 .
PMID
30794726 .
^
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice , Cell Metabolism 24, 795–806, December 13, 2016 ª 2016 Elsevier Inc.
^ Bondarenko, TI (2011). "Mechanism of delta-sleep inducing peptide geroprotective activity". Adv Gerontol . 24 (1): 80–92.
PMID
21809625 .
External links