From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Glycoprotein hormone beta-5 is a
protein that in humans is encoded by the GPHB5
gene .
[5]
GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002).[supplied by OMIM]
[5]
References
Z. Gong, W. Wang, K. El Omari, A. A. Lebedev, O. B. Clarke, W. A. Hendrickson, Crystal structure of LGR ligand alpha2/beta5 from Caenorhabditis elegans with implications for the evolution of glycoprotein hormones. Proc Natl Acad Sci U S A 120 (1), e2218630120 (2023).
https://www.pnas.org/doi/10.1073/pnas.2218630120#
Further reading
Okada SL, Ellsworth JL, Durnam DM, et al. (2006).
"A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor" . Mol. Endocrinol . 20 (2): 414–25.
doi :
10.1210/me.2005-0270 .
PMID
16210345 .
Sudo S, Kuwabara Y, Park JI, et al. (2005).
"Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5" . Endocrinology . 146 (8): 3596–604.
doi :
10.1210/en.2005-0317 .
PMID
15890769 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Heilig R, Eckenberg R, Petit JL, et al. (2003).
"The DNA sequence and analysis of human chromosome 14" . Nature . 421 (6923): 601–7.
Bibcode :
2003Natur.421..601H .
doi :
10.1038/nature01348 .
PMID
12508121 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Hsu SY, Nakabayashi K, Bhalla A (2003).
"Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5" . Mol. Endocrinol . 16 (7): 1538–51.
doi :
10.1210/mend.16.7.0871 .
PMID
12089349 .
Nakabayashi K, Matsumi H, Bhalla A, et al. (2002).
"Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor" . J. Clin. Invest . 109 (11): 1445–52.
doi :
10.1172/JCI14340 .
PMC
150994 .
PMID
12045258 .