Frank Kane may refer to:
- Frank Kane (author) (1912–1968), American detective fiction writer
- Frank Kane (baseball) (1895–1962), American MLB baseball player
- Francis Kane (ice hockey) (1923–2016), Canadian NHL, hockey player
- Frank E. Kane (born 1932), Canadian politician in the Legislative Assembly of New Brunswick
- Frank Caine (1881–1930), Australian rules footballer
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disambiguation page lists articles about people with the same name.
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