DescriptionVaginal cornification with a single subcutaneous injection of estrone or estradiol in aqueous suspension in women.png
English: Mean vaginal cornification (grade) with a single subcutaneous injection of different doses of estrone (2.0 mg, 4.0 mg) or estradiol (0.5 mg, 1.0 mg) in aqueous suspension in around 10 ovariectomized and menopausal women each. Grading is as follows:
1 (+) = 10–25% cornification of vaginal epithelial cells
2 (++) = 25–50% cornification of vaginal epithelial cells
3 (+++) = 50–75% cornification of vaginal epithelial cells
Sources of the values:
(April 1949). "The effects of various estrogenic preparations; changes in the vaginal mucosa and general status of climacteric women following the injection of aqueous suspensions of estrone and estradiol". Am. J. Obstet. Gynecol.57 (4): 682–91. DOI:
10.1016/0002-9378(49)90707-3. PMID18124553.
(July 1949). "The effects of various estrogenic preparations; the influence of equivalent amounts of several estrogens on the vaginal mucosa of nonmenstruating women". Am. J. Obstet. Gynecol.58 (1): 147–52. DOI:
10.1016/0002-9378(49)90017-4. PMID18151173.
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