DescriptionBi-directional modulation of AMPA receptor.png
English: A model for the mechanisms of depotentiation (DP) and de novo LTD. Rectangles represent AMPARs, open circles transmitter vesicles. (A) DP is due to a reduction in the number of surface-expressed AMPARs (DPN) when preceded by LTPN. Depression below the original baseline is due to a further reduction in AMPA receptor number causing a complete loss of postsynaptic receptors at some synapses. De novo LTD is due to the same mechanism. (B) DP is due to a reduction in γ (DPγ) when preceded by LTPγ.
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{{Information |Description = A model for the mechanisms of DP and de novo LTD. Rectangles represent AMPARs, open circles transmitter vesicles. (A) DP is due to a reduction in the number of surface-expressed AMPARs (DPN) when preceded by LTPN. Depressi
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