From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Fasciculation and elongation protein zeta-1 is a
protein that in humans is encoded by the FEZ1
gene .
[5]
[6]
[7]
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.
[7]
This protein is present in
neurons , and it is believed to block the process of infection of these cells by
HIV .
[8]
Interactions
FEZ1 has been shown to
interact with
Protein kinase Mζ ,
[9]
NBR1
[10] and
DISC1 .
[11]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000149557 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000032118 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Bloom L, Horvitz HR (May 1997).
"The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation" . Proc Natl Acad Sci U S A . 94 (7): 3414–9.
Bibcode :
1997PNAS...94.3414B .
doi :
10.1073/pnas.94.7.3414 .
PMC
20384 .
PMID
9096408 .
^ Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, Tanaka S, Fujita T, Kuroda S, Nagashima K, Sawa H (Jun 2005).
"Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation" . J Biol Chem . 280 (26): 24948–56.
doi :
10.1074/jbc.M411499200 .
PMID
15843383 .
^
a
b
"Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)" .
^ Haedicke, J.; Brown, C.; Naghavi, M. H. (Aug 2009).
"The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection" . Proceedings of the National Academy of Sciences . 106 (33): 14040–14045.
Bibcode :
2009PNAS..10614040H .
doi :
10.1073/pnas.0900502106 .
ISSN
0027-8424 .
PMC
2729016 .
PMID
19667186 .
^ Kuroda, S; Nakagawa N; Tokunaga C; Tatematsu K; Tanizawa K (Feb 1999).
"Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein" . J. Cell Biol . 144 (3): 403–11.
doi :
10.1083/jcb.144.3.403 .
ISSN
0021-9525 .
PMC
2132904 .
PMID
9971736 .
^ Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002).
"NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube" . Eur. J. Biochem . 269 (2): 538–45.
doi :
10.1046/j.0014-2956.2001.02681.x .
ISSN
0014-2956 .
PMID
11856312 .
^ Miyoshi, K; Honda A; Baba K; Taniguchi M; Oono K; Fujita T; Kuroda S; Katayama T; Tohyama M (Jul 2003).
"Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth" . Mol. Psychiatry . 8 (7): 685–94.
doi :
10.1038/sj.mp.4001352 .
ISSN
1359-4184 .
PMID
12874605 .
Further reading
Kuroda S, Nakagawa N, Tokunaga C, et al. (1999).
"Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein" . J. Cell Biol . 144 (3): 403–11.
doi :
10.1083/jcb.144.3.403 .
PMC
2132904 .
PMID
9971736 .
Whitehouse C, Chambers J, Howe K, et al. (2002).
"NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube" . Eur. J. Biochem . 269 (2): 538–45.
doi :
10.1046/j.0014-2956.2001.02681.x .
PMID
11856312 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Miyoshi K, Honda A, Baba K, et al. (2004).
"Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth" . Mol. Psychiatry . 8 (7): 685–94.
doi :
10.1038/sj.mp.4001352 .
PMID
12874605 .
Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry . 42 (51): 15369–76.
doi :
10.1021/bi034575v .
PMID
14690447 .
Goehler H, Lalowski M, Stelzl U, et al. (2004).
"A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease" . Mol. Cell . 15 (6): 853–65.
doi :
10.1016/j.molcel.2004.09.016 .
PMID
15383276 .
Okumura F, Hatakeyama S, Matsumoto M, et al. (2005).
"Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis" . J. Biol. Chem . 279 (51): 53533–43.
doi :
10.1074/jbc.M402916200 .
PMID
15466860 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Yamada K, Nakamura K, Minabe Y, et al. (2005). "Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts". Biol. Psychiatry . 56 (9): 683–90.
doi :
10.1016/j.biopsych.2004.08.015 .
PMID
15522253 .
S2CID
42525017 .
Stelzl U, Worm U, Lalowski M, et al. (2005).
"A human protein-protein interaction network: a resource for annotating the proteome" . Cell . 122 (6): 957–68.
doi :
10.1016/j.cell.2005.08.029 .
hdl :
11858/00-001M-0000-0010-8592-0 .
PMID
16169070 .
S2CID
8235923 .
Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006).
"FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region" . J. Biol. Chem . 281 (15): 9869–81.
doi :
10.1074/jbc.M513280200 .
PMID
16484223 .
Blasius TL, Cai D, Jih GT, et al. (2007).
"Two binding partners cooperate to activate the molecular motor Kinesin-1" . J. Cell Biol . 176 (1): 11–7.
doi :
10.1083/jcb.200605099 .
PMC
2063617 .
PMID
17200414 .
Koga M, Ishiguro H, Horiuchi Y, et al. (2007). "Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population". Neurosci. Lett . 417 (3): 326–9.
doi :
10.1016/j.neulet.2007.02.055 .
PMID
17374448 .
S2CID
33689793 .