Fatty acid-binding protein 2 (FABP2), also known as Intestinal-type fatty acid-binding protein (I-FABP), is a
protein that in humans is encoded by the FABP2gene.[5]
Function
The intracellular
fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of
long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine
epithelial cells.[5]
Clinical significance
This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a
threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and
insulin resistance.[5]
Edwards A, Hammond HA, Jin L, et al. (1992). "Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups". Genomics. 12 (2): 241–53.
doi:
10.1016/0888-7543(92)90371-X.
PMID1740333.
Goold RD, diSibio GL, Xu H, et al. (1993). "The development of sequence-tagged sites for human chromosome 4". Hum. Mol. Genet. 2 (8): 1271–88.
doi:
10.1093/hmg/2.8.1271.
PMID8401509.
Prochazka M, Lillioja S, Tait JF, et al. (1993). "Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians". Diabetes. 42 (4): 514–9.
doi:
10.2337/diabetes.42.4.514.
PMID8454101.
Zhang F, Lücke C, Baier LJ, et al. (1997). "Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit". J. Biomol. NMR. 9 (3): 213–28.
doi:
10.1023/A:1018666522787.
PMID9204553.
S2CID24409209.
Darimont C, Gradoux N, Cumin F, et al. (1998). "Differential regulation of intestinal and liver fatty acid-binding proteins in human intestinal cell line (Caco-2): role of collagen". Exp. Cell Res. 244 (2): 441–7.
doi:
10.1006/excr.1998.4186.
PMID9806794.
Darimont C, Gradoux N, de Pover A (1999). "Epidermal growth factor regulates fatty acid uptake and metabolism in Caco-2 cells". Am. J. Physiol. 276 (3 Pt 1): G606–12.
doi:
10.1152/ajpgi.1999.276.3.G606.
PMID10070036.