Escherichia coli (AIEC) NC101 is a mouse isolate,
serotype O2:H6/41, that is
pro-carcinogenic, adherent-invasive (AIEC),
probiotic strain of
Escherichia coli, a species of
bacteria that thrives in the
intestines of
mammals.[1][2] NC101 has also been identified as a
nicotinic acid (NA)
auxotroph, a pathobiont, which is an organism that is harmful under certain circumstances,[3] and is an important, relevant model organism that demonstrates how susceptible individuals may produce inappropriate immune responses to seemingly benign intestinal E. coli.[4]
E. coli NC101 has been found to promote carcinoma specifically,
mucinous adenocarcinoma, in while performing experiments in
azoxymethane treated mice. The findings of the study found "...
tumorigenesis by altering microbial composition and inducing the expansion of microorganisms with
genotoxic capabilities."[6] The frequency of specific E. coli strains like NC101 in laboratory mouse colonies is currently unknown.[citation needed]